The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The long and the short of it -A perspective on peptidergic regulation of circuits and behaviour

The long and the short of it -A perspective on peptidergic regulation of circuits and behaviour
The long and the short of it -A perspective on peptidergic regulation of circuits and behaviour

Neuropeptides are the most diverse class of chemical modulators in nervous systems. They contribute to extensive modulation of circuit activity and have profound influences on animal physiology. Studies on invertebrate model organisms, including the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, have enabled the genetic manipulation of peptidergic signalling, contributing to an understanding of how neuropeptides pattern the output of neural circuits to underpin behavioural adaptation. Electrophysiological and pharmacological analyses of well-defined microcircuits, such as the crustacean stomatogastric ganglion, have provided detailed insights into neuropeptide functions at a cellular and circuit level. These approaches can be increasingly applied in the mammalian brain by focusing on circuits with a defined and identifiable sub-population of neurons. Functional analyses of neuropeptide systems have been underpinned by systematic studies to map peptidergic networks. Here, we review the general principles and mechanistic insights that have emerged from these studies. We also highlight some of the challenges that remain for furthering our understanding of the functional relevance of peptidergic modulation.

Invertebrate, Model system, Modulation, Neuropeptide, Plasticity
0022-0949
Jékely, Gáspár
94f0485f-2d93-4df4-b287-1e5b01295578
Melzer, Sarah
f2d2db0b-590d-4d60-ba9e-c616a46c5ce7
Beets, Isabel
ff535b52-ab02-4013-872f-4ff8d5c80da4
Kadow, Ilona C.Grunwald
6fb1e4dd-efb1-45e0-8fba-414fd2543b3e
Koene, Joris
8ec24717-f7e5-4cd9-850a-d3b6fb56fc8f
Haddad, Sara
a1689eb9-c709-4d43-88e0-8496797a708b
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Jékely, Gáspár
94f0485f-2d93-4df4-b287-1e5b01295578
Melzer, Sarah
f2d2db0b-590d-4d60-ba9e-c616a46c5ce7
Beets, Isabel
ff535b52-ab02-4013-872f-4ff8d5c80da4
Kadow, Ilona C.Grunwald
6fb1e4dd-efb1-45e0-8fba-414fd2543b3e
Koene, Joris
8ec24717-f7e5-4cd9-850a-d3b6fb56fc8f
Haddad, Sara
a1689eb9-c709-4d43-88e0-8496797a708b
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e

Jékely, Gáspár, Melzer, Sarah, Beets, Isabel, Kadow, Ilona C.Grunwald, Koene, Joris, Haddad, Sara and Holden-Dye, Lindy (2018) The long and the short of it -A perspective on peptidergic regulation of circuits and behaviour. Journal of Experimental Biology, 221 (3), [166710]. (doi:10.1242/jeb.166710).

Record type: Review

Abstract

Neuropeptides are the most diverse class of chemical modulators in nervous systems. They contribute to extensive modulation of circuit activity and have profound influences on animal physiology. Studies on invertebrate model organisms, including the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, have enabled the genetic manipulation of peptidergic signalling, contributing to an understanding of how neuropeptides pattern the output of neural circuits to underpin behavioural adaptation. Electrophysiological and pharmacological analyses of well-defined microcircuits, such as the crustacean stomatogastric ganglion, have provided detailed insights into neuropeptide functions at a cellular and circuit level. These approaches can be increasingly applied in the mammalian brain by focusing on circuits with a defined and identifiable sub-population of neurons. Functional analyses of neuropeptide systems have been underpinned by systematic studies to map peptidergic networks. Here, we review the general principles and mechanistic insights that have emerged from these studies. We also highlight some of the challenges that remain for furthering our understanding of the functional relevance of peptidergic modulation.

Text
JEKELY_et_al - Accepted Manuscript
Download (2MB)

More information

e-pub ahead of print date: 8 February 2018
Published date: February 2018
Keywords: Invertebrate, Model system, Modulation, Neuropeptide, Plasticity

Identifiers

Local EPrints ID: 418696
URI: http://eprints.soton.ac.uk/id/eprint/418696
ISSN: 0022-0949
PURE UUID: e5f63317-2b78-406f-8a85-98d071e115f1
ORCID for Lindy Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217

Catalogue record

Date deposited: 19 Mar 2018 17:30
Last modified: 26 Nov 2021 06:37

Export record

Altmetrics

Contributors

Author: Gáspár Jékely
Author: Sarah Melzer
Author: Isabel Beets
Author: Ilona C.Grunwald Kadow
Author: Joris Koene
Author: Sara Haddad

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×