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A genetically selected cyclic peptide inhibitor of BCL6 homodimerization

A genetically selected cyclic peptide inhibitor of BCL6 homodimerization
A genetically selected cyclic peptide inhibitor of BCL6 homodimerization
We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.
0968-0896
Osher, Eliot
bcaf2f72-05de-41b2-aa0d-995f4c66d8f0
Castillo Correa, Francisco
e99a4b66-a412-4c99-a87d-f981d8769c67
Elumalai, Nagarajan
906d0161-3780-4778-ba5e-86ce313faf8d
Waring, Michael J.
778971c0-a442-4808-ad80-b333f3dc1597
Pairaudeau, Garry
896e9bfc-e1ad-47ae-b18a-009f69395061
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Osher, Eliot
bcaf2f72-05de-41b2-aa0d-995f4c66d8f0
Castillo Correa, Francisco
e99a4b66-a412-4c99-a87d-f981d8769c67
Elumalai, Nagarajan
906d0161-3780-4778-ba5e-86ce313faf8d
Waring, Michael J.
778971c0-a442-4808-ad80-b333f3dc1597
Pairaudeau, Garry
896e9bfc-e1ad-47ae-b18a-009f69395061
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2

Osher, Eliot, Castillo Correa, Francisco, Elumalai, Nagarajan, Waring, Michael J., Pairaudeau, Garry and Tavassoli, Ali (2018) A genetically selected cyclic peptide inhibitor of BCL6 homodimerization. Bioorganic & Medicinal Chemistry. (doi:10.1016/j.bmc.2018.03.012).

Record type: Article

Abstract

We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.

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Osher et al - Accepted Manuscript
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Accepted/In Press date: 7 March 2018
e-pub ahead of print date: 9 March 2018
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Identifiers

Local EPrints ID: 418876
URI: http://eprints.soton.ac.uk/id/eprint/418876
DOI: doi:10.1016/j.bmc.2018.03.012
ISSN: 0968-0896
PURE UUID: f57c6e24-a4f2-44ab-b49a-a9061448ed2f
ORCID for Nagarajan Elumalai: ORCID iD orcid.org/0000-0001-7359-5218
ORCID for Ali Tavassoli: ORCID iD orcid.org/0000-0002-7420-5063

Catalogue record

Date deposited: 23 Mar 2018 17:30
Last modified: 11 May 2024 04:01

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Contributors

Author: Eliot Osher
Author: Francisco Castillo Correa
Author: Nagarajan Elumalai ORCID iD
Author: Michael J. Waring
Author: Garry Pairaudeau
Author: Ali Tavassoli ORCID iD

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