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Measurement of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults: a reliability study

Measurement of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults: a reliability study
Measurement of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults: a reliability study
Purpose: Reliability of motor evoked potential threshold and amplitude measurement of upper limb muscles is important when detecting changes in cortical excitability. The objective of this study was to investigate intra-rater, test-retest reliability and minimal detectable change of resting motor threshold and amplitude of a proximal and distal upper limb muscles, anterior deltoid and distal extensor digitorum communis, in healthy adults.
Method: To measure MEP responses, transcranial magnetic stimulation was interfaced with electromyography and neuronavigation equipment. Two measurements were conducted on day one and a third measurement three days later. Reliability was analysed using intraclass correlation coefficients.
Results: Twenty participants completed the study. Excellent intra-rater (ICC=0.91[extensor digitorum], 0.94[anterior deltoid]) and good to excellent test-retest reliability (ICC=0.69[anterior deltoid], 0.84[extensor digitorum]) was found for resting motor threshold. Minimal detectable change for resting motor threshold was found at 10.95% [extensor digitorum] and 16.35% [anterior deltoid] between first and third measurements. Motor evoked potential amplitude of EDC had fair to good inta-rater (ICC=0.50) and test-retest reliability (ICC=0.65).
Conclusions: Our results suggest that resting motor threshold is a reliable neurophysiological measure even for proximal shoulder muscles. Future research should further explore the reliability of motor evoked potential amplitude before integration into neurological rehabilitation.
2055-6683
1-17
Tedesco Triccas, Lisa
c9f22c5c-3f36-42cb-a233-4198096ffc44
Hughes, Ann-Marie
11239f51-de47-4445-9a0d-5b82ddc11dea
Burridge, Jane
0110e9ea-0884-4982-a003-cb6307f38f64
Din, Amy, Elizabeth
90f6f38e-8b75-413b-ac0e-b2eb50beeea7
Warner, Martin
f4dce73d-fb87-4f71-a3f0-078123aa040c
Brown, Simon
81f6a7a5-379f-4b86-8b55-39f9799c23c8
Tedesco Triccas, Lisa
c9f22c5c-3f36-42cb-a233-4198096ffc44
Hughes, Ann-Marie
11239f51-de47-4445-9a0d-5b82ddc11dea
Burridge, Jane
0110e9ea-0884-4982-a003-cb6307f38f64
Din, Amy, Elizabeth
90f6f38e-8b75-413b-ac0e-b2eb50beeea7
Warner, Martin
f4dce73d-fb87-4f71-a3f0-078123aa040c
Brown, Simon
81f6a7a5-379f-4b86-8b55-39f9799c23c8

Tedesco Triccas, Lisa, Hughes, Ann-Marie, Burridge, Jane, Din, Amy, Elizabeth, Warner, Martin and Brown, Simon (2018) Measurement of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults: a reliability study. Journal of Rehabilitation and Assistive Technologies Engineering (RATE), 1-17. (doi:10.1177/2055668318765406).

Record type: Article

Abstract

Purpose: Reliability of motor evoked potential threshold and amplitude measurement of upper limb muscles is important when detecting changes in cortical excitability. The objective of this study was to investigate intra-rater, test-retest reliability and minimal detectable change of resting motor threshold and amplitude of a proximal and distal upper limb muscles, anterior deltoid and distal extensor digitorum communis, in healthy adults.
Method: To measure MEP responses, transcranial magnetic stimulation was interfaced with electromyography and neuronavigation equipment. Two measurements were conducted on day one and a third measurement three days later. Reliability was analysed using intraclass correlation coefficients.
Results: Twenty participants completed the study. Excellent intra-rater (ICC=0.91[extensor digitorum], 0.94[anterior deltoid]) and good to excellent test-retest reliability (ICC=0.69[anterior deltoid], 0.84[extensor digitorum]) was found for resting motor threshold. Minimal detectable change for resting motor threshold was found at 10.95% [extensor digitorum] and 16.35% [anterior deltoid] between first and third measurements. Motor evoked potential amplitude of EDC had fair to good inta-rater (ICC=0.50) and test-retest reliability (ICC=0.65).
Conclusions: Our results suggest that resting motor threshold is a reliable neurophysiological measure even for proximal shoulder muscles. Future research should further explore the reliability of motor evoked potential amplitude before integration into neurological rehabilitation.

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Measurement of motor evoked potential resting threshold and amplitude of proximal and distal arm muscles in healthy adults. A reliability study - Accepted Manuscript
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Accepted/In Press date: 19 February 2018
e-pub ahead of print date: 2 April 2018

Identifiers

Local EPrints ID: 419002
URI: http://eprints.soton.ac.uk/id/eprint/419002
ISSN: 2055-6683
PURE UUID: 5a115e8b-adc0-4201-b732-a7e66cee9ba3
ORCID for Ann-Marie Hughes: ORCID iD orcid.org/0000-0002-3958-8206
ORCID for Jane Burridge: ORCID iD orcid.org/0000-0003-3497-6725
ORCID for Martin Warner: ORCID iD orcid.org/0000-0002-1483-0561
ORCID for Simon Brown: ORCID iD orcid.org/0000-0001-9646-3285

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Date deposited: 27 Mar 2018 16:30
Last modified: 18 Feb 2021 17:09

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Contributors

Author: Lisa Tedesco Triccas
Author: Jane Burridge ORCID iD
Author: Amy, Elizabeth Din
Author: Martin Warner ORCID iD
Author: Simon Brown ORCID iD

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