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Harnessing nanotopography to enhance osseointegration of clinical orthopedic titanium implants-an in vitro and in vivo analysis

Harnessing nanotopography to enhance osseointegration of clinical orthopedic titanium implants-an in vitro and in vivo analysis
Harnessing nanotopography to enhance osseointegration of clinical orthopedic titanium implants-an in vitro and in vivo analysis

Despite technological advancements, further innovations in the field of orthopedics and bone regeneration are essential to meet the rising demands of an increasing aging population and associated issues of disease, injury and trauma. Nanotopography provides new opportunities for novel implant surface modifications and promises to deliver further improvements in implant performance. However, the technical complexities of nanotopography fabrication and surface analysis have precluded identification of the optimal surface features to trigger osteogenesis. We herein detail the osteoinductive potential of discrete nanodot and nanowire nanotopographies. We have examined the ability of modified titanium and titanium alloy (Ti64) surfaces to induce bone-specific gene activation and extracellular matrix protein expression in human skeletal stem cells (SSCs) in vitro, and de novo osteogenic response within a murine calvarial model in vivo. This study provides evidence of enhanced osteogenic response to nanowires 300 surface modifications, with important implications for clinical orthopedic application.

1-16
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
Hulsart-Billstrom, Gry
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Sjostrom, Terje
c1615dd5-a794-4b7a-ad5e-eff8df229b59
Dunlop, Douglas G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
Hulsart-Billstrom, Gry
41799212-48c4-4791-9a24-9090a77ba6cc
Sjostrom, Terje
c1615dd5-a794-4b7a-ad5e-eff8df229b59
Dunlop, Douglas G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Goriainov, Vitali, Hulsart-Billstrom, Gry, Sjostrom, Terje, Dunlop, Douglas G., Su, Bo and Oreffo, Richard O.C. (2018) Harnessing nanotopography to enhance osseointegration of clinical orthopedic titanium implants-an in vitro and in vivo analysis. Frontiers in Bioengineering and Biotechnology, 6 (APR), 1-16, [44]. (doi:10.3389/fbioe.2018.00044).

Record type: Article

Abstract

Despite technological advancements, further innovations in the field of orthopedics and bone regeneration are essential to meet the rising demands of an increasing aging population and associated issues of disease, injury and trauma. Nanotopography provides new opportunities for novel implant surface modifications and promises to deliver further improvements in implant performance. However, the technical complexities of nanotopography fabrication and surface analysis have precluded identification of the optimal surface features to trigger osteogenesis. We herein detail the osteoinductive potential of discrete nanodot and nanowire nanotopographies. We have examined the ability of modified titanium and titanium alloy (Ti64) surfaces to induce bone-specific gene activation and extracellular matrix protein expression in human skeletal stem cells (SSCs) in vitro, and de novo osteogenic response within a murine calvarial model in vivo. This study provides evidence of enhanced osteogenic response to nanowires 300 surface modifications, with important implications for clinical orthopedic application.

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More information

Accepted/In Press date: 27 March 2018
e-pub ahead of print date: 11 April 2018
Published date: 11 April 2018

Identifiers

Local EPrints ID: 419344
URI: http://eprints.soton.ac.uk/id/eprint/419344
PURE UUID: 18ca2aac-b2a0-4963-bcda-16f9e6989858
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 11 Apr 2018 16:30
Last modified: 26 Nov 2021 05:59

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Contributors

Author: Vitali Goriainov
Author: Gry Hulsart-Billstrom
Author: Terje Sjostrom
Author: Douglas G. Dunlop
Author: Bo Su

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