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Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire Cohort Study

Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire Cohort Study
Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire Cohort Study
Mini AbstractThis study investigated the association between mild cognitive impairment (MCI) and physical function and bone health in older adults. MCI was associated with poor physical performance but not bone mineral density or bone microarchitecture.AbstractPurpose: Cross-sectional study to investigate the association between mild cognitive impairment (MCI) and physical performance, and bone health, in a community-dwelling cohort of older adults.Methods: Cognitive function of 222 men and 221 women (mean age 75.5 and 75.8 years in men and women, respectively) was assessed by the Strawbridge questionnaire and Mini Mental State Exam (MMSE). Participants underwent dual-energy x-ray absorptiometry (DXA), peripheral-quantitative computed tomography (pQCT) and high-resolution peripheral-quantitative computed tomography (HR-pQCT) scans to assess their bone density, strength and microarchitecture. Their physical function was assessed and a physical performance (PP) score was recorded.Results: 11.8% of women and 8.1% of men in the study were cognitive impaired on the MMSE (score<24). 24% of women were deemed cognitively impaired on the Strawbridge questionnaire, compared to 22.3% of men. Cognitive impairment on the Strawbridge questionnaire was associated with poorer physical performance score in men but not women in the unadjusted analysis. MMSE <24 was strongly associated with the risk of low physical performance in men (OR 12.9, 95% CI 1.67, 99.8, p=0.01) Higher MMSE score was associated with better physical performance in both sexes. Poorer cognitive function, whether assessed by the Strawbridge questionnaire, or by MMSE score, was not associated with bone density, shape or microarchitecture, in either sex.Conclusion: MCI in older adults was associated with poor physical performance, but not bone density, shape or microarchitecture.
1862-3522
Patel, A.
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Jameson, K.A.
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Edwards, M.H.
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Ward, K.
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Gale, C.R.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Patel, A.
05f1956d-b07c-45f0-9283-3e461d8a12fa
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Edwards, M.H.
8d92e1ef-8d4d-4efa-a183-305cd9ca1125
Ward, K.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1

Patel, A., Jameson, K.A., Edwards, M.H., Ward, K., Gale, C.R., Cooper, C. and Dennison, E.M. (2018) Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire Cohort Study. Archives of Osteoporosis, 13 (44). (doi:10.1007/s11657-018-0455-3).

Record type: Article

Abstract

Mini AbstractThis study investigated the association between mild cognitive impairment (MCI) and physical function and bone health in older adults. MCI was associated with poor physical performance but not bone mineral density or bone microarchitecture.AbstractPurpose: Cross-sectional study to investigate the association between mild cognitive impairment (MCI) and physical performance, and bone health, in a community-dwelling cohort of older adults.Methods: Cognitive function of 222 men and 221 women (mean age 75.5 and 75.8 years in men and women, respectively) was assessed by the Strawbridge questionnaire and Mini Mental State Exam (MMSE). Participants underwent dual-energy x-ray absorptiometry (DXA), peripheral-quantitative computed tomography (pQCT) and high-resolution peripheral-quantitative computed tomography (HR-pQCT) scans to assess their bone density, strength and microarchitecture. Their physical function was assessed and a physical performance (PP) score was recorded.Results: 11.8% of women and 8.1% of men in the study were cognitive impaired on the MMSE (score<24). 24% of women were deemed cognitively impaired on the Strawbridge questionnaire, compared to 22.3% of men. Cognitive impairment on the Strawbridge questionnaire was associated with poorer physical performance score in men but not women in the unadjusted analysis. MMSE <24 was strongly associated with the risk of low physical performance in men (OR 12.9, 95% CI 1.67, 99.8, p=0.01) Higher MMSE score was associated with better physical performance in both sexes. Poorer cognitive function, whether assessed by the Strawbridge questionnaire, or by MMSE score, was not associated with bone density, shape or microarchitecture, in either sex.Conclusion: MCI in older adults was associated with poor physical performance, but not bone density, shape or microarchitecture.

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MCI vs Bone and PP final version March 2018 - Accepted Manuscript
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Accepted/In Press date: 28 March 2018
e-pub ahead of print date: 24 April 2018
Published date: December 2018

Identifiers

Local EPrints ID: 419941
URI: https://eprints.soton.ac.uk/id/eprint/419941
ISSN: 1862-3522
PURE UUID: c89055a8-d205-4e90-8bc6-981b8b8e4f9f
ORCID for K. Ward: ORCID iD orcid.org/0000-0001-7034-6750
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 24 Apr 2018 16:30
Last modified: 20 Jul 2019 04:21

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