Are the effects of methylphenidate uncertain?
Are the effects of methylphenidate uncertain?
Objectives:
A recent systematic review and meta-analysis of randomised controlled trials of methylphenidate (MPH) in children and adolescents by a Cochrane group, led by Storebø, raised concern around the level of evidence supporting the use of this medication for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This led to several critical responses from a number of ADHD experts.
Methods:
This paper reviews the conclusions reached from the Storebø meta-analysis by a critical analysis of methodologies used along with drawing on extant literature.
Results:
The controversy raised by the Cochrane meta-analysis should lead to a balanced reflection on the research priorities and needs for the field.
Conclusions:
It is hoped the controversy will ultimately lead to improve the quality of the research on the efficacy, effectiveness and tolerability of MPH for ADHD.
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Cortese, Samuele
(2018)
Are the effects of methylphenidate uncertain?
Irish Journal of Psychological Medicine.
(doi:10.1017/ipm.2018.16).
Abstract
Objectives:
A recent systematic review and meta-analysis of randomised controlled trials of methylphenidate (MPH) in children and adolescents by a Cochrane group, led by Storebø, raised concern around the level of evidence supporting the use of this medication for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This led to several critical responses from a number of ADHD experts.
Methods:
This paper reviews the conclusions reached from the Storebø meta-analysis by a critical analysis of methodologies used along with drawing on extant literature.
Results:
The controversy raised by the Cochrane meta-analysis should lead to a balanced reflection on the research priorities and needs for the field.
Conclusions:
It is hoped the controversy will ultimately lead to improve the quality of the research on the efficacy, effectiveness and tolerability of MPH for ADHD.
Text
Cortese_R1_BLACK
- Accepted Manuscript
More information
Accepted/In Press date: 29 March 2018
e-pub ahead of print date: 6 May 2018
Identifiers
Local EPrints ID: 420009
URI: http://eprints.soton.ac.uk/id/eprint/420009
PURE UUID: b448d770-cb15-4cb0-84df-77a5ef96d831
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Date deposited: 25 Apr 2018 16:30
Last modified: 16 Mar 2024 06:29
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