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Novel approach to estimate Osteoarthritis progression - use of the reliable change index in the evaluation of joint space loss

Novel approach to estimate Osteoarthritis progression - use of the reliable change index in the evaluation of joint space loss
Novel approach to estimate Osteoarthritis progression - use of the reliable change index in the evaluation of joint space loss
Objective Osteoarthritis‐related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3‐year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results Between consecutive years, 57–69% of participants had an apparent decrease (change <0) in JSW, while 31–43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. Conclusion The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.
0893-7524
300-307
Parsons, Camille
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Judge, Andrew
b853f89f-dc44-428e-9fe2-35e925544abe
Leyland, Kirsten M.
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Bruyere, Olivier
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Petit Dop, Florence
0af40637-efb0-4e14-a41f-9a6c9f891916
Chapurlat, Roland
d9410f8c-4e4a-465b-8fb6-67efaadaad4c
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Edwards, Mark
0b95b131-86cc-4ee7-b5fd-4694d9acbf0d
Dennison, Elaine
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
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The SEKOIA Study Group
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Judge, Andrew
b853f89f-dc44-428e-9fe2-35e925544abe
Leyland, Kirsten M.
1fa50316-86aa-43f9-b37e-d9d0111de19c
Bruyere, Olivier
7d127754-d7d6-4328-8f76-212df27727b6
Petit Dop, Florence
0af40637-efb0-4e14-a41f-9a6c9f891916
Chapurlat, Roland
d9410f8c-4e4a-465b-8fb6-67efaadaad4c
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Edwards, Mark
0b95b131-86cc-4ee7-b5fd-4694d9acbf0d
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7

Parsons, Camille, Judge, Andrew, Leyland, Kirsten M., Bruyere, Olivier, Petit Dop, Florence, Chapurlat, Roland, Reginster, Jean-Yves, Edwards, Mark, Dennison, Elaine, Cooper, Cyrus and Inskip, Hazel , The SEKOIA Study Group (2019) Novel approach to estimate Osteoarthritis progression - use of the reliable change index in the evaluation of joint space loss. Arthritis Care & Research, 71 (2), 300-307. (doi:10.1002/acr.23596).

Record type: Article

Abstract

Objective Osteoarthritis‐related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. Methods Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3‐year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. Results Between consecutive years, 57–69% of participants had an apparent decrease (change <0) in JSW, while 31–43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. Conclusion The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.

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Arthritis Care and Research-RCI manuscript CLEAN - Accepted Manuscript
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Accepted/In Press date: 1 May 2018
e-pub ahead of print date: 9 May 2018
Published date: February 2019

Identifiers

Local EPrints ID: 420734
URI: http://eprints.soton.ac.uk/id/eprint/420734
ISSN: 0893-7524
PURE UUID: 0df03333-3283-48f2-8ff7-d207591e8273
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

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Date deposited: 14 May 2018 16:30
Last modified: 26 Nov 2021 05:28

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Contributors

Author: Camille Parsons
Author: Andrew Judge
Author: Kirsten M. Leyland
Author: Olivier Bruyere
Author: Florence Petit Dop
Author: Roland Chapurlat
Author: Jean-Yves Reginster
Author: Mark Edwards
Author: Elaine Dennison ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Hazel Inskip ORCID iD
Corporate Author: The SEKOIA Study Group

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