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Adiposity and cortisol response to stress in Indian adolescents

Adiposity and cortisol response to stress in Indian adolescents
Adiposity and cortisol response to stress in Indian adolescents

SETTING: Holdsworth Memorial Hospital, Mysore, India.

OBJECTIVE: We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C).

DESIGN: Descriptive study.

PARTICIPANTS: Adolescents aged 13.5y from a birth cohort were recruited (N=269, 133 boys).

METHODS: The stressor (TSST-C) was 5-minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar 'judges'. Salivary cortisol concentrations were measured at baseline and at regular intervals after TSST-C. Weight, height, sub scapular and triceps skinfold thickness, and waist and hip circumference were measured, and percentage body fat was estimated (fat%; bioimpedance). Body mass index (BMI) and Waist-to-hip ratio (WHR) were calculated. All variables were converted into within-cohort SD scores before analysis. Stress-induced change in cortisol concentrations from baseline (cortisol response) was examined in relation to adiposity.

RESULTS: Stress increased cortisol concentrations significantly from baseline (mean (SD): 5.5 (6.4) ng/mL; P<0.001). Higher WHR was associated with lower cortisol response at 20 and 30-minutes after stress (~0.13 SD decrease in cortisol response per SD higher WHR, P<0.05). Higher fat% was also associated with lower cortisol response only in girls 20-minutes post-stress (0.23 SD lower response per SD higher fat%, P=0.004). Sum of skinfold thickness and BMI were not associated with cortisol responses.

CONCLUSION: Abdominal adiposity is associated with reduced hypothalamic-pituitary-adrenal axis reactivity to stress in this adolescent population.

0019-6061
125-130
Krishnaveni, G.V.
eb73f522-17b0-4aa9-a7c7-df0014ced8c3
Jones, A.
81853a11-7995-4590-a888-0e2807ae379a
Veena, S.R.
379349f3-cee7-4a58-93b2-1caa5271118e
Somashekara, R.
163434c9-e4b2-4847-92cc-9e24c6341d6c
Karat, S.C.
6d394c4d-6f7a-43eb-b53b-e03b6be85a0c
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Krishnaveni, G.V.
eb73f522-17b0-4aa9-a7c7-df0014ced8c3
Jones, A.
81853a11-7995-4590-a888-0e2807ae379a
Veena, S.R.
379349f3-cee7-4a58-93b2-1caa5271118e
Somashekara, R.
163434c9-e4b2-4847-92cc-9e24c6341d6c
Karat, S.C.
6d394c4d-6f7a-43eb-b53b-e03b6be85a0c
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18

Krishnaveni, G.V., Jones, A., Veena, S.R., Somashekara, R., Karat, S.C. and Fall, C.H.D. (2018) Adiposity and cortisol response to stress in Indian adolescents. Indian pediatrics, 55 (2), 125-130. (doi:10.1007/s13312-018-1244-1).

Record type: Article

Abstract

SETTING: Holdsworth Memorial Hospital, Mysore, India.

OBJECTIVE: We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C).

DESIGN: Descriptive study.

PARTICIPANTS: Adolescents aged 13.5y from a birth cohort were recruited (N=269, 133 boys).

METHODS: The stressor (TSST-C) was 5-minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar 'judges'. Salivary cortisol concentrations were measured at baseline and at regular intervals after TSST-C. Weight, height, sub scapular and triceps skinfold thickness, and waist and hip circumference were measured, and percentage body fat was estimated (fat%; bioimpedance). Body mass index (BMI) and Waist-to-hip ratio (WHR) were calculated. All variables were converted into within-cohort SD scores before analysis. Stress-induced change in cortisol concentrations from baseline (cortisol response) was examined in relation to adiposity.

RESULTS: Stress increased cortisol concentrations significantly from baseline (mean (SD): 5.5 (6.4) ng/mL; P<0.001). Higher WHR was associated with lower cortisol response at 20 and 30-minutes after stress (~0.13 SD decrease in cortisol response per SD higher WHR, P<0.05). Higher fat% was also associated with lower cortisol response only in girls 20-minutes post-stress (0.23 SD lower response per SD higher fat%, P=0.004). Sum of skinfold thickness and BMI were not associated with cortisol responses.

CONCLUSION: Abdominal adiposity is associated with reduced hypothalamic-pituitary-adrenal axis reactivity to stress in this adolescent population.

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Accepted/In Press date: 4 October 2017
e-pub ahead of print date: 14 December 2017
Published date: 15 February 2018

Identifiers

Local EPrints ID: 420748
URI: http://eprints.soton.ac.uk/id/eprint/420748
ISSN: 0019-6061
PURE UUID: 7e641b85-09d5-4183-aa26-ab62556a6de0
ORCID for C.H.D. Fall: ORCID iD orcid.org/0000-0003-4402-5552

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Date deposited: 15 May 2018 16:30
Last modified: 18 Feb 2021 16:37

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Contributors

Author: G.V. Krishnaveni
Author: A. Jones
Author: S.R. Veena
Author: R. Somashekara
Author: S.C. Karat
Author: C.H.D. Fall ORCID iD

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