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Nitrate measurement in droplet flow: gas-mediated crosstalk and correction

Nitrate measurement in droplet flow: gas-mediated crosstalk and correction
Nitrate measurement in droplet flow: gas-mediated crosstalk and correction
In droplet microfluidics, droplets have traditionally been considered discrete self-contained reaction chambers, however recent work has shown that dissolved solutes can transfer into the oil phase and migrate into neighbouring droplets under certain conditions. The majority of reports on such interdroplet
“crosstalk” have focused on surfactant-driven mechanisms, such as transport within micelles. While trialling a droplet-based system for quantifying nitrate in water, we encountered crosstalk driven by a very different mechanism: conversion of the analyte to a gaseous intermediate which subsequently diffused between droplets. Importantly we found that the crosstalk occurred predictably, could be experimentally quantified, and measurements rationally post-corrected. This showed that droplet microfluidic systems susceptible to crosstalk such as this can nonetheless be used for quantitative analysis.
1473-0197
Nightingale, Adrian
4b51311d-c6c3-40d5-a13f-ab8917031ab3
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Evans, Gareth, William Harry
235f863f-e661-464e-ba15-79faa28c6d77
Coleman, Sharon
2653c332-2105-46b7-98ca-450d88a3aa9f
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
Nightingale, Adrian
4b51311d-c6c3-40d5-a13f-ab8917031ab3
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Evans, Gareth, William Harry
235f863f-e661-464e-ba15-79faa28c6d77
Coleman, Sharon
2653c332-2105-46b7-98ca-450d88a3aa9f
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa

Nightingale, Adrian, Hassan, Sammer-Ul, Evans, Gareth, William Harry, Coleman, Sharon and Niu, Xize (2018) Nitrate measurement in droplet flow: gas-mediated crosstalk and correction. Lab on a Chip, [10.1039/C8LC00092A]. (doi:10.1039/C8LC00092A).

Record type: Article

Abstract

In droplet microfluidics, droplets have traditionally been considered discrete self-contained reaction chambers, however recent work has shown that dissolved solutes can transfer into the oil phase and migrate into neighbouring droplets under certain conditions. The majority of reports on such interdroplet
“crosstalk” have focused on surfactant-driven mechanisms, such as transport within micelles. While trialling a droplet-based system for quantifying nitrate in water, we encountered crosstalk driven by a very different mechanism: conversion of the analyte to a gaseous intermediate which subsequently diffused between droplets. Importantly we found that the crosstalk occurred predictably, could be experimentally quantified, and measurements rationally post-corrected. This showed that droplet microfluidic systems susceptible to crosstalk such as this can nonetheless be used for quantitative analysis.

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Nitrate measurement in droplet flow - Accepted Manuscript
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Accepted/In Press date: 1 June 2018
e-pub ahead of print date: 4 June 2018

Identifiers

Local EPrints ID: 421703
URI: http://eprints.soton.ac.uk/id/eprint/421703
ISSN: 1473-0197
PURE UUID: a38670e2-b9e0-422d-b34f-ec0badc9314d
ORCID for Sammer-Ul Hassan: ORCID iD orcid.org/0000-0002-0319-5814

Catalogue record

Date deposited: 21 Jun 2018 16:30
Last modified: 26 Nov 2021 05:47

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Contributors

Author: Gareth, William Harry Evans
Author: Sharon Coleman
Author: Xize Niu

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