Sgalla, Giacomo, Walsh, Simon, Sverzellati, Nicola, Fletcher, Sophie, Cerri, Stefania, Dimitrov, Borislav, Nikolic, Dragana, Barney, Anna, Pancaldi, Fabrizio, Larcher, Luca, Luppi, Fabrizio, Jones, Mark, Davies, Donna and Richeldi, Luca (2018) “Velcro-type” crackles predict specific radiologic features of fibrotic interstitial lung disease. BMC Pulmonary Medicine, 18 (1), [103]. (doi:10.1186/s12890-018-0670-0).
Abstract
Background: “Velcro-type” crackles on chest auscultation are considered a typical acoustic finding of Fibrotic Interstitial Lung Disease (FILD), however whether they may have a role in the early detection of these disorders has been unknown. This study investigated how “Velcro-type” crackles correlate with the presence of distinct patterns of FILD and individual radiologic features of pulmonary fibrosis on High Resolution Computed Tomography (HRCT).
Methods: lung sounds were digitally recorded from subjects immediately prior to undergoing clinically indicated chest HRCT. Audio files were independently assessed by two chest physicians and both full volume and single HRCT sections corresponding to the recording sites were extracted. The relationships between audible “Velcro-type” crackles and radiologic HRCT patterns and individual features of pulmonary fibrosis were investigated using multivariate regression models.
Results: 148 subjects were enrolled: bilateral “Velcro-type” crackles predicted the presence of FILD at HRCT (OR 13.46, 95% CI 5.85–30.96, p < 0.001) and most strongly the Usual Interstitial Pneumonia (UIP) pattern (OR 19.8, 95% CI 5.28–74. 25, p < 0.001). Extent of isolated reticulation (OR 2.04, 95% CI 1.62–2.57, p < 0.001), honeycombing (OR 1.88, 95% CI 1. 24–2.83, < 0.01), ground glass opacities (OR 1.74, 95% CI 1.29–2.32, p < 0.001) and traction bronchiectasis (OR 1.55, 95% CI 1.03–2.32, p < 0.05) were all independently associated with the presence of “Velcro-type” crackles.
Conclusions: “Velcro-type” crackles predict the presence of FILD and directly correlate with the extent of distinct radiologic features of pulmonary fibrosis. Such evidence provides grounds for further investigation of lung sounds as an early identification tool in FILD.
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- Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Inst. Sound & Vibration Research (pre 2018 reorg)
Current Faculties > Faculty of Engineering and Physical Sciences > School of Engineering > Institute of Sound and Vibration Research > Inst. Sound & Vibration Research (pre 2018 reorg)
Institute of Sound and Vibration Research > Inst. Sound & Vibration Research (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Medicine (pre 2018 reorg) > Primary Care & Population Sciences (pre 2018 reorg)
Current Faculties > Faculty of Medicine > Primary Care, Population Sciences and Medical Education > Primary Care & Population Sciences (pre 2018 reorg)
Primary Care, Population Sciences and Medical Education > Primary Care & Population Sciences (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Southampton Marine & Maritime Institute (pre 2018 reorg)
- Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Inst. Sound & Vibration Research (pre 2018 reorg) > Signal Processing & Control Grp (pre 2018 reorg)
Current Faculties > Faculty of Engineering and Physical Sciences > School of Engineering > Institute of Sound and Vibration Research > Inst. Sound & Vibration Research (pre 2018 reorg) > Signal Processing & Control Grp (pre 2018 reorg)
Institute of Sound and Vibration Research > Inst. Sound & Vibration Research (pre 2018 reorg) > Signal Processing & Control Grp (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Medicine (pre 2018 reorg) > Clinical & Experimental Sciences (pre 2018 reorg)
Current Faculties > Faculty of Medicine > Clinical and Experimental Sciences > Clinical & Experimental Sciences (pre 2018 reorg)
Clinical and Experimental Sciences > Clinical & Experimental Sciences (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Institute for Life Sciences (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
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