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Cost-effective but clinically inappropriate: New NICE intervention thresholds in osteoporosis (Technology Appraisal 464)

Cost-effective but clinically inappropriate: New NICE intervention thresholds in osteoporosis (Technology Appraisal 464)
Cost-effective but clinically inappropriate: New NICE intervention thresholds in osteoporosis (Technology Appraisal 464)

Purpose: to comment on the latest technology appraisal of the National Institute for Clinical Excellence (NICE) in osteoporosis. 

Methods: review of NICE Technology Appraisal (TA464) on bisphosphonate use in osteoporosis. 

Results: the NICE appraisal on bisphosphonate use in osteoporosis indicates that treatment with oral bisphosphonates may be instituted at a FRAX 10-year probability of major osteoporotic fracture above 1%. Implementation would mean that all women aged 50 years or older are deemed eligible for treatment, a position that would increase the burden of rare long-term side effects across the population. 

Conclusion: cost-effectiveness thresholds for low-cost interventions should not be used to set intervention thresholds but rather to validate the implementation of clinically driven intervention thresholds.

0937-941X
1511-1513
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, E.
5211de37-303a-42f8-b24b-00c475264f78
Kanis, J.A.
55c6bd2c-d653-48de-b4b9-29fe280fb00f
Compston, J.
b64c0d0e-97dd-44c8-97ba-f756f0bc966d
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, E.
5211de37-303a-42f8-b24b-00c475264f78
Kanis, J.A.
55c6bd2c-d653-48de-b4b9-29fe280fb00f
Compston, J.
b64c0d0e-97dd-44c8-97ba-f756f0bc966d
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Harvey, N.C., McCloskey, E., Kanis, J.A., Compston, J. and Cooper, C. (2018) Cost-effective but clinically inappropriate: New NICE intervention thresholds in osteoporosis (Technology Appraisal 464). Osteoporosis International, 1511-1513. (doi:10.1007/s00198-018-4505-x).

Record type: Article

Abstract

Purpose: to comment on the latest technology appraisal of the National Institute for Clinical Excellence (NICE) in osteoporosis. 

Methods: review of NICE Technology Appraisal (TA464) on bisphosphonate use in osteoporosis. 

Results: the NICE appraisal on bisphosphonate use in osteoporosis indicates that treatment with oral bisphosphonates may be instituted at a FRAX 10-year probability of major osteoporotic fracture above 1%. Implementation would mean that all women aged 50 years or older are deemed eligible for treatment, a position that would increase the burden of rare long-term side effects across the population. 

Conclusion: cost-effectiveness thresholds for low-cost interventions should not be used to set intervention thresholds but rather to validate the implementation of clinically driven intervention thresholds.

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NICE BP editorial OSIN R1 - Accepted Manuscript
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More information

Accepted/In Press date: 19 January 2018
e-pub ahead of print date: 8 June 2018
Published date: July 2018

Identifiers

Local EPrints ID: 422052
URI: https://eprints.soton.ac.uk/id/eprint/422052
ISSN: 0937-941X
PURE UUID: c27bcdd5-fd9b-4db3-9a7f-336f0a90cb94
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 13 Jul 2018 16:30
Last modified: 10 Dec 2019 05:19

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