Effect of intra-myocardial algisyl-LVR™ injectates on fiber structure in porcine heart failure

Abstract

Recent preclinical trials have shown that alginate injections are a promising treatment for ischemic heart disease. Although improvements in heart function and global structure have been reported following alginate implants, the underlying structure is poorly understood. Using high resolution ex vivo MRI and DT-MRI of the hearts of normal control swine (n=8), swine with induced heart failure (n=5), and swine with heart failure and alginate injection treatment (n=6), we visualized and quantified the fiber distribution and implant material geometry. Our findings show that the alginate injectates form solid ellipsoids with a retention rate of 68.7%±21.3% (mean±SD) and a sphericity index of 0.37±0.03. These ellipsoidal shapes solidified predominantly at the mid-wall position with an inclination of -4.9°±31.4° relative to the local circumferential direction. Overall, the change to left ventricular wall thickness and myofiber orientation was minor and was associated with heart failure and not the presence of injectates. These results show that alginate injectates conform to the pre-existing tissue structure, likely expanding along directions of least resistance as mass is added to the injection sites. The alginate displaces the myocardial tissue predominantly in the longitudinal direction, causing minimal disruption to the surrounding myofiber orientations.

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