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Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older

Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older
Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older

Summary: We studied the incidence of subsequent fractures in persons of 50+ years from 1990 to 2012 and the relative risk (RR) of subsequent fractures after an index femur/hip fracture, stratified per 5-year age band. Patients suffering a fracture have a high incidence of a subsequent fracture; the RR of subsequent fracture after a femur/hip fracture ranged from 2 to 7. Introduction: Recent information on the risk of subsequent fractures after a broad range of index fractures in the UK population is scarce. We therefore studied the rates of subsequent fractures of the femur/hip, humerus, radius/ulna, vertebrae, rib, or pelvis after fractures at one of these sites from 1990 to 2012 in 3,156,347 UK men and women aged 50 years or over. Methods: We undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD). The incidence of subsequent fractures at a specific site was calculated by dividing the observed number of fractures by the number of person-years (py) at risk. The relative risk (RR) of subsequent fractures after a femur/hip fracture, by 5-year age band, was calculated by dividing the incidence of a specific subsequent fracture type by the incidence of first fractures at the same site in the same age group. Results: The highest subsequent fracture incidence after a femur/hip fracture was for humerus fracture in men (59.5/10.000 py) and radius/ulna fracture in women (117.2/10.000 py). After an index fracture of the radius/ulna, humerus fracture in men (59.3/10.000 py) and femur/hip fracture in women (82.4 per 10.000 py) were most frequent. The RR of fractures after a femur/hip fracture ranged from 2 to 7 and were highest in men and younger age groups. Conclusion: Patients suffering a fracture have a high incidence of a subsequent fracture. Our findings demonstrate the importance of fracture prevention in patients with a history of a fracture by adequate medical diagnosis and treatment.

0937-941X
van der Velde, R. Y.
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Wyers, C. E.
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Geusens, P. P.M.M.
283a5cbd-bd2c-4a19-8549-24f24b3bf0ad
van den Bergh, J. P.W.
c30fc1ae-c65a-4c7e-a71f-cfd251a8b8b5
de Vries, F.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
van de Staa, T. P.
438cdc38-714e-48f4-8eb5-41b0de820064
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145
van der Velde, R. Y.
fb7773ca-97e5-4650-994f-f98825c9c7cd
Wyers, C. E.
3fe3e040-7070-476b-a0f1-bb4cac288886
Geusens, P. P.M.M.
283a5cbd-bd2c-4a19-8549-24f24b3bf0ad
van den Bergh, J. P.W.
c30fc1ae-c65a-4c7e-a71f-cfd251a8b8b5
de Vries, F.
10245a32-6083-4feb-9d20-7e7db0f358b1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
van de Staa, T. P.
438cdc38-714e-48f4-8eb5-41b0de820064
Harvey, N. C.
ce487fb4-d360-4aac-9d17-9466d6cba145

van der Velde, R. Y., Wyers, C. E., Geusens, P. P.M.M., van den Bergh, J. P.W., de Vries, F., Cooper, C., van de Staa, T. P. and Harvey, N. C. (2018) Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older. Osteoporosis International. (doi:10.1007/s00198-018-4636-0).

Record type: Article

Abstract

Summary: We studied the incidence of subsequent fractures in persons of 50+ years from 1990 to 2012 and the relative risk (RR) of subsequent fractures after an index femur/hip fracture, stratified per 5-year age band. Patients suffering a fracture have a high incidence of a subsequent fracture; the RR of subsequent fracture after a femur/hip fracture ranged from 2 to 7. Introduction: Recent information on the risk of subsequent fractures after a broad range of index fractures in the UK population is scarce. We therefore studied the rates of subsequent fractures of the femur/hip, humerus, radius/ulna, vertebrae, rib, or pelvis after fractures at one of these sites from 1990 to 2012 in 3,156,347 UK men and women aged 50 years or over. Methods: We undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD). The incidence of subsequent fractures at a specific site was calculated by dividing the observed number of fractures by the number of person-years (py) at risk. The relative risk (RR) of subsequent fractures after a femur/hip fracture, by 5-year age band, was calculated by dividing the incidence of a specific subsequent fracture type by the incidence of first fractures at the same site in the same age group. Results: The highest subsequent fracture incidence after a femur/hip fracture was for humerus fracture in men (59.5/10.000 py) and radius/ulna fracture in women (117.2/10.000 py). After an index fracture of the radius/ulna, humerus fracture in men (59.3/10.000 py) and femur/hip fracture in women (82.4 per 10.000 py) were most frequent. The RR of fractures after a femur/hip fracture ranged from 2 to 7 and were highest in men and younger age groups. Conclusion: Patients suffering a fracture have a high incidence of a subsequent fracture. Our findings demonstrate the importance of fracture prevention in patients with a history of a fracture by adequate medical diagnosis and treatment.

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Accepted/In Press date: 9 July 2018
e-pub ahead of print date: 20 July 2018

Identifiers

Local EPrints ID: 422293
URI: https://eprints.soton.ac.uk/id/eprint/422293
ISSN: 0937-941X
PURE UUID: a4a11326-33ee-4fd8-929a-57e57441b703
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for N. C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 20 Jul 2018 16:30
Last modified: 10 Dec 2019 05:18

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