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Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Objectives:

To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi‐national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes.

Particpants and Methods:

Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36‐item short‐form health survey (SF‐36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale‐Revised, risk perception and knowledge. The results of the baseline questionnaire are presented.

Results:

A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF‐36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status.

Conclusion:

This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer‐specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
1464-4096
Bancroft, Elizabeth K.
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Saya, Sibel
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Page, Elizabeth C.
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Myhill, Kathryn
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Thomas, Sarah
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Pope, Jennifer
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Chamberlain, Anthony
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Hart, Rachel
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Glover, Wayne
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Cook, Jackie
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Rosario, Derek J.
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Helfand, Brian T.
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Hutten Selkirk, Christina
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Davidson, Rosemarie
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Longmuir, Mark
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Eccles, Diana M.
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Gadea, Neus
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Brewer, Carole
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Barwell, Julian
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Salinas, Monica
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Greenhalgh, Lynn
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Tischkowitz, Marc
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Henderson, Alex
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Evans, David Gareth
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Buys, Saundra S.
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Eeles, Rosalind A.
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Aaronson, Neil K.
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Bancroft, Elizabeth K.
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Saya, Sibel
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Page, Elizabeth C.
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Myhill, Kathryn
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Thomas, Sarah
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Pope, Jennifer
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Chamberlain, Anthony
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Hart, Rachel
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Glover, Wayne
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Cook, Jackie
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Rosario, Derek J.
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Helfand, Brian T.
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Hutten Selkirk, Christina
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Davidson, Rosemarie
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Longmuir, Mark
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Eccles, Diana M.
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Gadea, Neus
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Brewer, Carole
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Barwell, Julian
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Salinas, Monica
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Greenhalgh, Lynn
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Tischkowitz, Marc
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Henderson, Alex
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Evans, David Gareth
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Buys, Saundra S.
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Eeles, Rosalind A.
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Aaronson, Neil K.
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Bancroft, Elizabeth K., Saya, Sibel, Page, Elizabeth C., Myhill, Kathryn, Thomas, Sarah, Pope, Jennifer, Chamberlain, Anthony, Hart, Rachel, Glover, Wayne, Cook, Jackie, Rosario, Derek J., Helfand, Brian T., Hutten Selkirk, Christina, Davidson, Rosemarie, Longmuir, Mark, Eccles, Diana M., Gadea, Neus, Brewer, Carole, Barwell, Julian, Salinas, Monica, Greenhalgh, Lynn, Tischkowitz, Marc, Henderson, Alex, Evans, David Gareth, Buys, Saundra S., Eeles, Rosalind A. and Aaronson, Neil K. (2018) Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations. BJU International. (doi:10.1111/bju.14412).

Record type: Article

Abstract


Objectives:

To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi‐national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes.

Particpants and Methods:

Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36‐item short‐form health survey (SF‐36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale‐Revised, risk perception and knowledge. The results of the baseline questionnaire are presented.

Results:

A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants’ perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF‐36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status.

Conclusion:

This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer‐specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

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IMPACT QoL FINAL DRAFT FOR CIRCULATION 04.01.2018 - Accepted Manuscript
Restricted to Repository staff only until 26 May 2019.
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Accepted/In Press date: 25 May 2018
e-pub ahead of print date: 26 May 2018

Identifiers

Local EPrints ID: 422451
URI: https://eprints.soton.ac.uk/id/eprint/422451
ISSN: 1464-4096
PURE UUID: b5a6fa8c-78b0-4acd-8f95-f91a1d4239cd

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Date deposited: 24 Jul 2018 16:30
Last modified: 13 Mar 2019 18:16

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Contributors

Author: Elizabeth K. Bancroft
Author: Sibel Saya
Author: Elizabeth C. Page
Author: Kathryn Myhill
Author: Sarah Thomas
Author: Jennifer Pope
Author: Anthony Chamberlain
Author: Rachel Hart
Author: Wayne Glover
Author: Jackie Cook
Author: Derek J. Rosario
Author: Brian T. Helfand
Author: Christina Hutten Selkirk
Author: Rosemarie Davidson
Author: Mark Longmuir
Author: Diana M. Eccles
Author: Neus Gadea
Author: Carole Brewer
Author: Julian Barwell
Author: Monica Salinas
Author: Lynn Greenhalgh
Author: Marc Tischkowitz
Author: Alex Henderson
Author: David Gareth Evans
Author: Saundra S. Buys
Author: Rosalind A. Eeles
Author: Neil K. Aaronson

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