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Regenerative medicine in lower limb reconstruction

Regenerative medicine in lower limb reconstruction
Regenerative medicine in lower limb reconstruction
Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function. In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this review, we will evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work.
1746-0751
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tribe, Howard, Clementi
1433f1d5-6e04-4d1a-8229-35b9bba9de5e
Jacobs, Neil
fa990ae3-d5c6-4483-a11f-462c705e9399
Hancock, N.
e179910d-232e-4cc3-a386-e7ae84735257
Qureshi, Amir
c817cdfa-cb62-42bd-a95c-8b977b12f0e4
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tribe, Howard, Clementi
1433f1d5-6e04-4d1a-8229-35b9bba9de5e
Jacobs, Neil
fa990ae3-d5c6-4483-a11f-462c705e9399
Hancock, N.
e179910d-232e-4cc3-a386-e7ae84735257
Qureshi, Amir
c817cdfa-cb62-42bd-a95c-8b977b12f0e4
Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d

Oreffo, Richard, Tribe, Howard, Clementi, Jacobs, Neil, Hancock, N., Qureshi, Amir and Dunlop, D.G. (2018) Regenerative medicine in lower limb reconstruction. Regenerative Medicine, 13 (4). (doi:10.2217/rme-2018-0011).

Record type: Article

Abstract

Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function. In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this review, we will evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work.

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More information

Accepted/In Press date: 15 May 2018
e-pub ahead of print date: 9 July 2018
Published date: 2018

Identifiers

Local EPrints ID: 422860
URI: http://eprints.soton.ac.uk/id/eprint/422860
ISSN: 1746-0751
PURE UUID: ed427843-e275-494c-bf3b-e13bc8f49462
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for Howard, Clementi Tribe: ORCID iD orcid.org/0000-0003-2011-4147

Catalogue record

Date deposited: 07 Aug 2018 16:30
Last modified: 07 Oct 2020 05:02

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