Regenerative medicine in lower limb reconstruction
Regenerative medicine in lower limb reconstruction
Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function. In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this review, we will evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work.
Oreffo, Richard
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Tribe, Howard, Clementi
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Jacobs, Neil
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Hancock, N.
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Qureshi, Amir
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Dunlop, D.G.
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2018
Oreffo, Richard
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Tribe, Howard, Clementi
1433f1d5-6e04-4d1a-8229-35b9bba9de5e
Jacobs, Neil
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Hancock, N.
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Qureshi, Amir
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Dunlop, D.G.
eb03bdad-6a88-4057-acd8-70a9271f629d
Oreffo, Richard, Tribe, Howard, Clementi, Jacobs, Neil, Hancock, N., Qureshi, Amir and Dunlop, D.G.
(2018)
Regenerative medicine in lower limb reconstruction.
Regenerative Medicine, 13 (4).
(doi:10.2217/rme-2018-0011).
Abstract
Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function. In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this review, we will evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work.
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rme-2018-0011
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Accepted/In Press date: 15 May 2018
e-pub ahead of print date: 9 July 2018
Published date: 2018
Identifiers
Local EPrints ID: 422860
URI: http://eprints.soton.ac.uk/id/eprint/422860
ISSN: 1746-0751
PURE UUID: ed427843-e275-494c-bf3b-e13bc8f49462
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Date deposited: 07 Aug 2018 16:30
Last modified: 09 Jan 2022 05:11
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Contributors
Author:
Howard, Clementi Tribe
Author:
Neil Jacobs
Author:
N. Hancock
Author:
Amir Qureshi
Author:
D.G. Dunlop
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