Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study
Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study
Background
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.
Methods
In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.
Results
Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.
Conclusions
Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
1-5
Haapanen, M.J.
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Perala, M.M.
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Osmond, C.
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Salonen, M.K.
afeb1f26-cc79-4b5f-a5e5-6bc490150047
Kajantie, E.
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Rantanen, T.
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Simonen, M.
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Pohjolainen, P.
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Eriksson, J.G.
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von Bonsdorff, M.B.
85cb5f12-9e2e-4069-ba39-a2d1f08d5fc0
Haapanen, M.J.
13b56c9a-a172-47b1-9692-5e9a01f0d377
Perala, M.M.
2eb306a3-7103-4877-81c9-858afc568af9
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Salonen, M.K.
afeb1f26-cc79-4b5f-a5e5-6bc490150047
Kajantie, E.
c1db7428-b2c0-46f9-92c3-bcd8cdd452fd
Rantanen, T.
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Simonen, M.
fdfb84c5-fac6-4805-873c-1f8f80783120
Pohjolainen, P.
40edd956-aa70-4f2d-9d8b-5bf4a7a557b3
Eriksson, J.G.
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von Bonsdorff, M.B.
85cb5f12-9e2e-4069-ba39-a2d1f08d5fc0
Haapanen, M.J., Perala, M.M., Osmond, C., Salonen, M.K., Kajantie, E., Rantanen, T., Simonen, M., Pohjolainen, P., Eriksson, J.G. and von Bonsdorff, M.B.
(2018)
Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.
Aging Clinical and Experimental Research, .
(doi:10.1007/s40520-018-1011-0).
Abstract
Background
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.
Methods
In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.
Results
Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.
Conclusions
Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Text
manuscript_R2
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More information
Accepted/In Press date: 14 July 2018
e-pub ahead of print date: 24 July 2018
Identifiers
Local EPrints ID: 422884
URI: http://eprints.soton.ac.uk/id/eprint/422884
ISSN: 1594-0667
PURE UUID: cd37d21f-f635-4c75-ba46-a595a3d924bc
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Date deposited: 07 Aug 2018 16:30
Last modified: 16 Mar 2024 06:57
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Contributors
Author:
M.J. Haapanen
Author:
M.M. Perala
Author:
M.K. Salonen
Author:
E. Kajantie
Author:
T. Rantanen
Author:
M. Simonen
Author:
P. Pohjolainen
Author:
J.G. Eriksson
Author:
M.B. von Bonsdorff
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