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Omega-3 fatty acids and leukocyte-endothelium adhesion: novel anti-atherosclerotic actions

Omega-3 fatty acids and leukocyte-endothelium adhesion: novel anti-atherosclerotic actions
Omega-3 fatty acids and leukocyte-endothelium adhesion: novel anti-atherosclerotic actions
Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel wall. Here, monocytes differentiate into macrophages and may become foam cells, contributing to the initiation and progression of an atherosclerotic plaque. The ability of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) to influence the expression of adhesion molecules by ECs and to modulate leukocyte-endothelial adhesion has been studied in cell culture using various types of ECs, in animal feeding studies and in human trials; the latter have tended to evaluate soluble forms of adhesion molecules that circulate in the bloodstream. These studies indicate that n-3 PUFAs (both eicosapentaenoic acid and docosahexaenoic acid) can decrease the expression of key adhesion molecules, such as vascular cell adhesion molecule 1, by ECs and that this results in decreased adhesive interactions between leukocytes and ECs. These findings suggest that n-3 PUFAs may lower leukocyte infiltration into the vascular wall, which could contribute to reduced atherosclerosis and lowered risk of cardiovascular disease.
1872-9452
169-181
Baker, Ella J.
d84609d1-b8f7-4feb-85ff-5196a50ecb94
Yusof, M. Hayati
1d4b2958-992e-43fa-b20e-138cfb67c0cd
Yaqoob, Parveen
cf36e1a9-b1a5-443a-994b-b5497fcf2b79
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Baker, Ella J.
d84609d1-b8f7-4feb-85ff-5196a50ecb94
Yusof, M. Hayati
1d4b2958-992e-43fa-b20e-138cfb67c0cd
Yaqoob, Parveen
cf36e1a9-b1a5-443a-994b-b5497fcf2b79
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Baker, Ella J., Yusof, M. Hayati, Yaqoob, Parveen, Miles, Elizabeth A. and Calder, Philip C. (2018) Omega-3 fatty acids and leukocyte-endothelium adhesion: novel anti-atherosclerotic actions. Molecular Aspects of Medicine, 64, 169-181. (doi:10.1016/j.mam.2018.08.002).

Record type: Article

Abstract

Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel wall. Here, monocytes differentiate into macrophages and may become foam cells, contributing to the initiation and progression of an atherosclerotic plaque. The ability of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) to influence the expression of adhesion molecules by ECs and to modulate leukocyte-endothelial adhesion has been studied in cell culture using various types of ECs, in animal feeding studies and in human trials; the latter have tended to evaluate soluble forms of adhesion molecules that circulate in the bloodstream. These studies indicate that n-3 PUFAs (both eicosapentaenoic acid and docosahexaenoic acid) can decrease the expression of key adhesion molecules, such as vascular cell adhesion molecule 1, by ECs and that this results in decreased adhesive interactions between leukocytes and ECs. These findings suggest that n-3 PUFAs may lower leukocyte infiltration into the vascular wall, which could contribute to reduced atherosclerosis and lowered risk of cardiovascular disease.

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More information

Accepted/In Press date: 9 August 2018
e-pub ahead of print date: 13 August 2018
Published date: December 2018

Identifiers

Local EPrints ID: 423116
URI: https://eprints.soton.ac.uk/id/eprint/423116
ISSN: 1872-9452
PURE UUID: f9159d84-0aec-4cb6-83b7-13bef2cbe9f1
ORCID for Elizabeth A. Miles: ORCID iD orcid.org/0000-0002-8643-0655

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Date deposited: 14 Aug 2018 16:30
Last modified: 14 Mar 2019 01:55

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Contributors

Author: Ella J. Baker
Author: M. Hayati Yusof
Author: Parveen Yaqoob
Author: Elizabeth A. Miles ORCID iD

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