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Early postnatal growth failure in preterm infants is not inevitable

Early postnatal growth failure in preterm infants is not inevitable
Early postnatal growth failure in preterm infants is not inevitable

Background: previously published data have demonstrated that preterm infants experience a fall across marked centile lines for weight in early life with early poor head growth also reported. This study describes a single neonatal unit's experience of longitudinal change in weight, head circumference (HC) and length in a cohort of preterm infants born <32 weeks' gestation. 

Methods: data were collected from a single neonatal unit between July 2012 and June 2017. This period followed the introduction of improved nutritional guidelines. Patients were grouped according to their gestational age at birth. Growth lines were constructed for weight, HC and length in each gestational age group from the median measures and compared with reference centile lines. 

Results: data were analysed from 396 patients consisting of 2808, 1991 and 2004 measures for weight, HC and length, respectively. Longitudinal growth plots did not show an initial absolute weight loss in any of the subgroups. Across all groups, the mean change in SD score between birth and 36 weeks was -0.27 (95% CI -0.39 to -0.15). 

Conclusions: this description of longitudinal growth in a cohort of preterm infants demonstrates that early postnatal growth failure is not inevitable, with most infants growing along a trajectory close to their birth centile. There is no evidence of a 2 marked centile line weight decrease or weight loss. These data provide evidence to suggest that extrauterine weight gain tracking centile lines can be achieved.

growth, neonatology, nutrition
1359-2998
F235-F241
Andrews, Edward Thomas
6fdf69d3-2e4c-4de4-8731-7d4ea531d1af
Ashton, James John
03369017-99b5-40ae-9a43-14c98516f37d
Pearson, Freya
1d52a3d9-8d84-481a-8274-81cbdccbc40a
Mark Beattie, R.
55d81c7b-08c9-4f42-b6d3-245869badb71
Johnson, Mark John
64135487-45a1-46a6-a34b-595143e3c9a6
Andrews, Edward Thomas
6fdf69d3-2e4c-4de4-8731-7d4ea531d1af
Ashton, James John
03369017-99b5-40ae-9a43-14c98516f37d
Pearson, Freya
1d52a3d9-8d84-481a-8274-81cbdccbc40a
Mark Beattie, R.
55d81c7b-08c9-4f42-b6d3-245869badb71
Johnson, Mark John
64135487-45a1-46a6-a34b-595143e3c9a6

Andrews, Edward Thomas, Ashton, James John, Pearson, Freya, Mark Beattie, R. and Johnson, Mark John (2019) Early postnatal growth failure in preterm infants is not inevitable. Archives of Disease in Childhood - Fetal and Neonatal Edition, 104 (3), F235-F241. (doi:10.1136/archdischild-2018-315082).

Record type: Article

Abstract

Background: previously published data have demonstrated that preterm infants experience a fall across marked centile lines for weight in early life with early poor head growth also reported. This study describes a single neonatal unit's experience of longitudinal change in weight, head circumference (HC) and length in a cohort of preterm infants born <32 weeks' gestation. 

Methods: data were collected from a single neonatal unit between July 2012 and June 2017. This period followed the introduction of improved nutritional guidelines. Patients were grouped according to their gestational age at birth. Growth lines were constructed for weight, HC and length in each gestational age group from the median measures and compared with reference centile lines. 

Results: data were analysed from 396 patients consisting of 2808, 1991 and 2004 measures for weight, HC and length, respectively. Longitudinal growth plots did not show an initial absolute weight loss in any of the subgroups. Across all groups, the mean change in SD score between birth and 36 weeks was -0.27 (95% CI -0.39 to -0.15). 

Conclusions: this description of longitudinal growth in a cohort of preterm infants demonstrates that early postnatal growth failure is not inevitable, with most infants growing along a trajectory close to their birth centile. There is no evidence of a 2 marked centile line weight decrease or weight loss. These data provide evidence to suggest that extrauterine weight gain tracking centile lines can be achieved.

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UNTRACKED_Early postnatal growth failure in preterm infants is not inevitable - Accepted Manuscript
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More information

Accepted/In Press date: 8 July 2018
e-pub ahead of print date: 22 August 2018
Published date: 1 May 2019
Keywords: growth, neonatology, nutrition

Identifiers

Local EPrints ID: 423341
URI: https://eprints.soton.ac.uk/id/eprint/423341
ISSN: 1359-2998
PURE UUID: e682275f-a838-400d-9164-181b187c7465

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Date deposited: 20 Sep 2018 16:30
Last modified: 09 Dec 2019 17:57

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