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A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse

A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse
A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse
Objective: The GH-2000 score has been developed as a powerful and unique technique to detect growth hormone misuse by sportsmen and women. The score depends upon the measurement of two growth hormone (GH) sensitive markers, insulin-like growth factor-I (IGF-I) and the amino-terminal pro-peptide of type III collagen (P-III-NP). It has been previously suggested that the score shows a positive age effect in male athletes, which could potentially place older male athletes at a disadvantage. The purpose of this note is to investigate the performance of a previously suggested correction term in two new and larger data sets.

Results: The GH-2000 score was calculated for 7307 samples obtained from 15 accredited WADA laboratories in 2017 and 3916 samples measured at Drug Control Centre, King's College London, UK between 2013 and 2017. The GH-2000 scores were investigated for positive age effects using standard regression modelling. As previously, all analyses confirmed a positive age effect. Applying the earlier suggested correction term of 0.032 x age showed a significant over-correction leading to a negative association of the GH-2000 score with age. We now suggest a smaller age correction of 0.020 x age which corresponds to the smallest effect found in the earlier studies.
1756-0500
Bohning, Dankmar
1df635d4-e3dc-44d0-b61d-5fd11f6434e1
Holt, R.I.G.
4adf9410-50f5-4578-bacc-e3e704c23fd3
Boehning, Walailuck
c0e89cb8-3d21-433c-8ca1-c1ee7c5bdfa6
Sonsken, Peter H.
566f9a8a-7019-4fe4-be60-54d2a08180bf
Cowan, David
22bdafa8-cee8-481a-97d5-2687fcf325ca
Bartlett, Christiaan
ed9cba27-96ef-419e-824b-fabab5c7cba8
Guha, Nishan
1b8c142c-82be-4fd3-be11-90db4270c551
Bohning, Dankmar
1df635d4-e3dc-44d0-b61d-5fd11f6434e1
Holt, R.I.G.
4adf9410-50f5-4578-bacc-e3e704c23fd3
Boehning, Walailuck
c0e89cb8-3d21-433c-8ca1-c1ee7c5bdfa6
Sonsken, Peter H.
566f9a8a-7019-4fe4-be60-54d2a08180bf
Cowan, David
22bdafa8-cee8-481a-97d5-2687fcf325ca
Bartlett, Christiaan
ed9cba27-96ef-419e-824b-fabab5c7cba8
Guha, Nishan
1b8c142c-82be-4fd3-be11-90db4270c551

Bohning, Dankmar, Holt, R.I.G., Boehning, Walailuck, Sonsken, Peter H., Cowan, David, Bartlett, Christiaan and Guha, Nishan (2018) A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse. BMC Research Notes, 11 (350). (doi:10.1186/s13104-018-3741-7).

Record type: Article

Abstract

Objective: The GH-2000 score has been developed as a powerful and unique technique to detect growth hormone misuse by sportsmen and women. The score depends upon the measurement of two growth hormone (GH) sensitive markers, insulin-like growth factor-I (IGF-I) and the amino-terminal pro-peptide of type III collagen (P-III-NP). It has been previously suggested that the score shows a positive age effect in male athletes, which could potentially place older male athletes at a disadvantage. The purpose of this note is to investigate the performance of a previously suggested correction term in two new and larger data sets.

Results: The GH-2000 score was calculated for 7307 samples obtained from 15 accredited WADA laboratories in 2017 and 3916 samples measured at Drug Control Centre, King's College London, UK between 2013 and 2017. The GH-2000 scores were investigated for positive age effects using standard regression modelling. As previously, all analyses confirmed a positive age effect. Applying the earlier suggested correction term of 0.032 x age showed a significant over-correction leading to a negative association of the GH-2000 score with age. We now suggest a smaller age correction of 0.020 x age which corresponds to the smallest effect found in the earlier studies.

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Overcorrection for age - Accepted Manuscript
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Accepted/In Press date: 28 August 2018
e-pub ahead of print date: 5 September 2018
Published date: 2018

Identifiers

Local EPrints ID: 423872
URI: https://eprints.soton.ac.uk/id/eprint/423872
ISSN: 1756-0500
PURE UUID: 91b5f295-912e-4db5-9268-901cc1722daa
ORCID for Dankmar Bohning: ORCID iD orcid.org/0000-0003-0638-7106

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Date deposited: 03 Oct 2018 16:30
Last modified: 14 Mar 2019 01:37

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