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Statin use and knee osteoarthritis outcomes: a longitudinal cohort study

Statin use and knee osteoarthritis outcomes: a longitudinal cohort study
Statin use and knee osteoarthritis outcomes: a longitudinal cohort study
Objective: statins have several pleiotropic effects, but the literature regarding the possible relationship between statins use and outcomes in knee osteoarthritis (OA) is limited. We investigated whether statins use is associated with lower risk of radiographic (ROA), radiographic symptomatic knee OA (SxOA) and pain in North American people.Methods: a total of 4,448 community-dwelling adults from the Osteoarthritis Initiative were followed-up for 4 years. Statins use (including the time from baseline and the type) was defined through self-report information and confirmed by a trained interviewer. Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam ≥14%.Results: at baseline, 1,127 participants (=25.3%) used statins. Based on a multivariable Poisson regression analysis with robust variance estimators, any statins use was not associated with lower risk of pain worsening (relative risk, RR=0.97; 95%CI, confidence intervals: 0.93-1.02), incident ROA or SxOA. However, statins use > 5 years (RR=0.91; 95%CI: 0.83-0.997) and atorvastatin use (RR=0.95; 95%CI: 0.91-0.996) were associated with a reduced risk of developing pain, whilst rosuvastatin to a higher risk (RR=1.18; 95%CI: 1.12-1.24). The adjustment for the propensity score confirmed these findings.Conclusion: the effect of statins use on knee OA outcomes remains unclear, although in our study those using statins for over five years and those using atorvastatin reported a significant lower risk of developing knee pain.
0893-7524
Veronese, Nicola
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Koyanagi, Ai
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Stubbs, Brendon
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Cooper, Cyrus
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Guglielmi, Giuseppe
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Rizzoli, Rene
e02c0d92-6da1-430c-a669-0c20e94a850a
Schofield, Patricia
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Punzi, Leonardo
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Al-Daghri, Nasser M.
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Smith, Lee
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Maggi, Stefania
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Reginster, Jean-Yves
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Veronese, Nicola
a9a97f63-a828-45a3-bae0-68182c5a44fd
Koyanagi, Ai
217cfa42-a476-47d9-b158-4cfc6aed2719
Stubbs, Brendon
1b1916f6-b2f8-4257-84de-0c7072c4c67a
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Guglielmi, Giuseppe
4ecb970d-d132-4c7d-ba2c-49d3491fd10b
Rizzoli, Rene
e02c0d92-6da1-430c-a669-0c20e94a850a
Schofield, Patricia
119b3f56-6d57-4b41-a544-541e471a2c67
Punzi, Leonardo
9eec4f61-c98c-4072-859a-1fdab57febea
Al-Daghri, Nasser M.
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Smith, Lee
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Maggi, Stefania
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Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492

Veronese, Nicola, Koyanagi, Ai, Stubbs, Brendon, Cooper, Cyrus, Guglielmi, Giuseppe, Rizzoli, Rene, Schofield, Patricia, Punzi, Leonardo, Al-Daghri, Nasser M., Smith, Lee, Maggi, Stefania and Reginster, Jean-Yves (2018) Statin use and knee osteoarthritis outcomes: a longitudinal cohort study. Arthritis Care and Research. (doi:10.1002/acr.23735).

Record type: Article

Abstract

Objective: statins have several pleiotropic effects, but the literature regarding the possible relationship between statins use and outcomes in knee osteoarthritis (OA) is limited. We investigated whether statins use is associated with lower risk of radiographic (ROA), radiographic symptomatic knee OA (SxOA) and pain in North American people.Methods: a total of 4,448 community-dwelling adults from the Osteoarthritis Initiative were followed-up for 4 years. Statins use (including the time from baseline and the type) was defined through self-report information and confirmed by a trained interviewer. Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam ≥14%.Results: at baseline, 1,127 participants (=25.3%) used statins. Based on a multivariable Poisson regression analysis with robust variance estimators, any statins use was not associated with lower risk of pain worsening (relative risk, RR=0.97; 95%CI, confidence intervals: 0.93-1.02), incident ROA or SxOA. However, statins use > 5 years (RR=0.91; 95%CI: 0.83-0.997) and atorvastatin use (RR=0.95; 95%CI: 0.91-0.996) were associated with a reduced risk of developing pain, whilst rosuvastatin to a higher risk (RR=1.18; 95%CI: 1.12-1.24). The adjustment for the propensity score confirmed these findings.Conclusion: the effect of statins use on knee OA outcomes remains unclear, although in our study those using statins for over five years and those using atorvastatin reported a significant lower risk of developing knee pain.

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Accepted/In Press date: 20 August 2018
e-pub ahead of print date: 24 August 2018

Identifiers

Local EPrints ID: 424535
URI: https://eprints.soton.ac.uk/id/eprint/424535
ISSN: 0893-7524
PURE UUID: 8c648e86-d200-439c-8701-0a85508fee8c
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 05 Oct 2018 11:38
Last modified: 17 Sep 2019 04:07

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Contributors

Author: Nicola Veronese
Author: Ai Koyanagi
Author: Brendon Stubbs
Author: Cyrus Cooper ORCID iD
Author: Giuseppe Guglielmi
Author: Rene Rizzoli
Author: Patricia Schofield
Author: Leonardo Punzi
Author: Nasser M. Al-Daghri
Author: Lee Smith
Author: Stefania Maggi
Author: Jean-Yves Reginster

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