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Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism

Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism
Background

Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.
Methods

We review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays.
Results

We summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review.
Conclusions

Many studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health.
0300-5771
James, P.
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Sajjadi, S.
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Tomar, A.S.
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Saffari, A.
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Fall, C.H.D.
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Prentice, A.M.
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Shrestha, S.
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Issarapu, P.
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Yadav, D.K.
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Kaur, L.
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Lillycrop, K.
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Silver, M.
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Chandak, G.R.
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James, P.
e8c9d2fb-933a-4890-91f9-ec02b0811971
Sajjadi, S.
b67abff1-5c06-45df-ac23-d6e6b9b6ffbe
Tomar, A.S.
e2569785-f177-4b7e-9a39-3aae563ca08e
Saffari, A.
8d84ef56-cea4-48d0-bc69-c790f5abaf3e
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Prentice, A.M.
79bebd56-9f48-4687-9fbc-708b6a418f37
Shrestha, S.
a1317ac1-6da8-4f72-8ae0-770f5ab253a3
Issarapu, P.
4451d6e9-35d6-4b9b-bfe4-0d7ff944558d
Yadav, D.K.
eedf8cb6-a5d1-486f-aeab-140ef6e731fa
Kaur, L.
42aff612-4034-4e60-a077-fbbca1386a5b
Lillycrop, K.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Silver, M.
78a3859c-e5d7-4e27-9c0d-0e4a414e3c64
Chandak, G.R.
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James, P., Sajjadi, S., Tomar, A.S., Saffari, A., Fall, C.H.D., Prentice, A.M., Shrestha, S., Issarapu, P., Yadav, D.K., Kaur, L., Lillycrop, K., Silver, M. and Chandak, G.R. (2018) Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism. International Journal of Epidemiology. (doi:10.1093/ije/dyy153).

Record type: Article

Abstract

Background

Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.
Methods

We review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays.
Results

We summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review.
Conclusions

Many studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health.

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Candidate gene review EMPHASIS study group_FINAL - Accepted Manuscript
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More information

Accepted/In Press date: 4 July 2018
e-pub ahead of print date: 17 August 2018

Identifiers

Local EPrints ID: 424560
URI: https://eprints.soton.ac.uk/id/eprint/424560
ISSN: 0300-5771
PURE UUID: ffec9230-79f6-4114-b276-2a8cf1a1a0be
ORCID for K. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489

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Date deposited: 05 Oct 2018 11:38
Last modified: 03 Dec 2019 05:13

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Contributors

Author: P. James
Author: S. Sajjadi
Author: A.S. Tomar
Author: A. Saffari
Author: C.H.D. Fall
Author: A.M. Prentice
Author: S. Shrestha
Author: P. Issarapu
Author: D.K. Yadav
Author: L. Kaur
Author: K. Lillycrop ORCID iD
Author: M. Silver
Author: G.R. Chandak

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