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Prevalence of and risk factors for gout in HIV positive adults: A case-control study

Prevalence of and risk factors for gout in HIV positive adults: A case-control study
Prevalence of and risk factors for gout in HIV positive adults: A case-control study
Gout is the most common inflammatory arthritis worldwide. Its principal risk factor is hyperuricaemia. While gout has been described in HIV patients and numerous more outdated anti-retroviral therapies (ARTs) have been implicated, there have been few recent studies. Our case–control study investigated the prevalence of and risk factors for gout in an established HIV cohort. Cases were identified from database searches using key search terms, with two age- and gender-matched controls. These were compared for demographic factors, co-morbidities, HIV factors and ART exposure. Forty-five cases with gout were identified (point prevalence 2.2%). All were male and were more likely than controls to be of black African origin. Hypertension was associated with an almost five-fold increased gout risk (OR 4.8, 95% CI 1.8–12.4). No individual drug or ART class was associated with gout in this study but exposure to non-nucleoside reverse transcriptase inhibitors had a significantly protective effect against the risk of gout (OR 0.3, 95% CI 0.1–0.9). Our data suggest that gout is common in HIV patients and that the traditional risk factors, especially hypertension, play a key role. Gout and hyperuricaemia should be regarded as a biomarker of cardiovascular disease in HIV patients as they are in the general population.
0956-4624
249-255
Nicholson, Prini
61e705ad-20a7-45cb-bdaf-7b12def6c9c8
Saunsbury, Emma
d934f4c6-373d-4c1c-8526-25342a3685bb
D'angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Churchill, Duncan
f3eb308f-0959-4753-84ad-2eb2c0d8a38e
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109
Nicholson, Prini
61e705ad-20a7-45cb-bdaf-7b12def6c9c8
Saunsbury, Emma
d934f4c6-373d-4c1c-8526-25342a3685bb
D'angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Churchill, Duncan
f3eb308f-0959-4753-84ad-2eb2c0d8a38e
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109

Nicholson, Prini, Saunsbury, Emma, D'angelo, Stefania, Churchill, Duncan and Walker-Bone, Karen (2019) Prevalence of and risk factors for gout in HIV positive adults: A case-control study. International Journal of STD & AIDS, 30 (3), 249-255. (doi:10.1177/0956462418799803).

Record type: Article

Abstract

Gout is the most common inflammatory arthritis worldwide. Its principal risk factor is hyperuricaemia. While gout has been described in HIV patients and numerous more outdated anti-retroviral therapies (ARTs) have been implicated, there have been few recent studies. Our case–control study investigated the prevalence of and risk factors for gout in an established HIV cohort. Cases were identified from database searches using key search terms, with two age- and gender-matched controls. These were compared for demographic factors, co-morbidities, HIV factors and ART exposure. Forty-five cases with gout were identified (point prevalence 2.2%). All were male and were more likely than controls to be of black African origin. Hypertension was associated with an almost five-fold increased gout risk (OR 4.8, 95% CI 1.8–12.4). No individual drug or ART class was associated with gout in this study but exposure to non-nucleoside reverse transcriptase inhibitors had a significantly protective effect against the risk of gout (OR 0.3, 95% CI 0.1–0.9). Our data suggest that gout is common in HIV patients and that the traditional risk factors, especially hypertension, play a key role. Gout and hyperuricaemia should be regarded as a biomarker of cardiovascular disease in HIV patients as they are in the general population.

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More information

Accepted/In Press date: 14 August 2018
e-pub ahead of print date: 4 November 2018
Published date: 1 March 2019

Identifiers

Local EPrints ID: 425311
URI: https://eprints.soton.ac.uk/id/eprint/425311
ISSN: 0956-4624
PURE UUID: 12a554bd-8921-4687-872c-232e01771d02
ORCID for Stefania D'angelo: ORCID iD orcid.org/0000-0002-7267-1837
ORCID for Karen Walker-Bone: ORCID iD orcid.org/0000-0002-5992-1459

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Date deposited: 12 Oct 2018 16:30
Last modified: 20 Jul 2019 04:06

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