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Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes

Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes
Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes

A total of 153 non-repeat Acinetobacter spp. clinical isolates obtained in 2015 from Hospital Sultanah Nur Zahirah (HSNZ) in Terengganu, Malaysia, were characterized. Identification of the isolates at species level was performed by ribosomal DNA restriction analysis (ARDRA) followed by sequencing of the rpoB gene. The majority of the isolates (n=128; 83.7 %) were A. baumannii while the rest were identified as A. nosocomialis (n=16), A. calcoaceticus (n=5), A. soli (n=2), A. berezeniae (n=1) and A. variabilis (n=1). Multidrug resistance (MDR) was most prevalent in A. baumannnii (66.4 %) whereas only one non-baumannii isolate (A. nosocomialis) was MDR. The blaOXA-23 gene was the predominant acquired carbapenemase gene (56.2 %) and was significantly associated (P<0.001) with carbapenem resistance. However, no significant association was found for carbapenem resistance and isolates that contained the ISAba1-blaOXA-51 configuration.

Acinetobacter baumannii, beta-lactamases, carbapenem resistance, multidrug resistance, non-baumannii Acinetobacter
0022-2615
1538-1543
Mohd Rani, Farahiyah
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A Rahman, Nor Iza
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Ismail, Salwani
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Abdullah, Fatimah Haslina
ed358a29-5c46-4f41-a666-8e68f37a5fa9
Othman, Norlela
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Alattraqchi, Ahmed Ghazi
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Cleary, David W.
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Clarke, Stuart C.
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Yeo, Chew Chieng
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Mohd Rani, Farahiyah
1a1e50e5-e44e-445e-83ef-c7039a713620
A Rahman, Nor Iza
c8250dae-dd75-446b-8b17-c2763f98c121
Ismail, Salwani
beb95eb3-3e79-4c48-a040-9994c7b5abce
Abdullah, Fatimah Haslina
ed358a29-5c46-4f41-a666-8e68f37a5fa9
Othman, Norlela
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Alattraqchi, Ahmed Ghazi
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Cleary, David W.
f4079c6d-d54b-4108-b346-b0069035bec0
Clarke, Stuart C.
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Yeo, Chew Chieng
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Mohd Rani, Farahiyah, A Rahman, Nor Iza, Ismail, Salwani, Abdullah, Fatimah Haslina, Othman, Norlela, Alattraqchi, Ahmed Ghazi, Cleary, David W., Clarke, Stuart C. and Yeo, Chew Chieng (2018) Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes. Journal of Medical Microbiology, 67 (11), 1538-1543. (doi:10.1099/jmm.0.000844).

Record type: Article

Abstract

A total of 153 non-repeat Acinetobacter spp. clinical isolates obtained in 2015 from Hospital Sultanah Nur Zahirah (HSNZ) in Terengganu, Malaysia, were characterized. Identification of the isolates at species level was performed by ribosomal DNA restriction analysis (ARDRA) followed by sequencing of the rpoB gene. The majority of the isolates (n=128; 83.7 %) were A. baumannii while the rest were identified as A. nosocomialis (n=16), A. calcoaceticus (n=5), A. soli (n=2), A. berezeniae (n=1) and A. variabilis (n=1). Multidrug resistance (MDR) was most prevalent in A. baumannnii (66.4 %) whereas only one non-baumannii isolate (A. nosocomialis) was MDR. The blaOXA-23 gene was the predominant acquired carbapenemase gene (56.2 %) and was significantly associated (P<0.001) with carbapenem resistance. However, no significant association was found for carbapenem resistance and isolates that contained the ISAba1-blaOXA-51 configuration.

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Second_Revised_Acinetobacter_AMR_Paper_for_JMM_2823_08_2018_29 - Accepted Manuscript
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Accepted/In Press date: 6 September 2018
e-pub ahead of print date: 25 September 2018
Published date: 1 November 2018
Keywords: Acinetobacter baumannii, beta-lactamases, carbapenem resistance, multidrug resistance, non-baumannii Acinetobacter

Identifiers

Local EPrints ID: 426244
URI: http://eprints.soton.ac.uk/id/eprint/426244
ISSN: 0022-2615
PURE UUID: e45ff847-b241-4e3b-9d77-e6619f413894
ORCID for David W. Cleary: ORCID iD orcid.org/0000-0003-4533-0700
ORCID for Stuart C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 20 Nov 2018 17:30
Last modified: 22 Nov 2021 06:57

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Contributors

Author: Farahiyah Mohd Rani
Author: Nor Iza A Rahman
Author: Salwani Ismail
Author: Fatimah Haslina Abdullah
Author: Norlela Othman
Author: Ahmed Ghazi Alattraqchi
Author: David W. Cleary ORCID iD
Author: Chew Chieng Yeo

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