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Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy

Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy
Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy
Aim In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. Methods Between May 2005 and January 2008, 523 patients enrolled into the Prospective Outcomes in Sporadic versus Hereditary breast cancer study entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy. Results Data from 380 patients were available. Mean (standard deviation [SD]) pre-treatment body mass index (BMI) was 26.3 [5.6] kg/m2; 30% women gained > 5% body weight during the study period. Lower BMI at diagnosis predicted greater subsequent post treatment weight gain (4.3% relative weight gain for those in the 1st quartile of BMI compared to 0.8% for those in the 4th quartile; r=-0.22; p<0.001). No link to chemotherapy regimens, cigarette smoking, previous parity or chemotherapy induced amenorrhoea was noted. A total of 44% of women had central obesity (post-treatment waist measurement of >88cm). Conclusions Almost a third of premenopausal patients receiving adjuvant chemotherapy for breast cancer will gain clinically significant weight and over 40% will have central obesity 12-months following diagnosis. A greater weight gain is predicted by lower pretreatment BMI.
0960-9776
1-6
Gandhi, Ashu
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Copson, Ellen
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Eccles, Diana
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Durcan, Lorraine
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Howell, Anthony
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Morris, Julie
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Howell, Sacha
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McDiarmid, Sarah
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Sellers, Katharine
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Gareth Evans, D.
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Harvie, Michelle
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Gandhi, Ashu
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Copson, Ellen
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Eccles, Diana
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Durcan, Lorraine
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Howell, Anthony
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Morris, Julie
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Howell, Sacha
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McDiarmid, Sarah
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Sellers, Katharine
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Gareth Evans, D.
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Harvie, Michelle
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Gandhi, Ashu, Copson, Ellen, Eccles, Diana, Durcan, Lorraine, Howell, Anthony, Morris, Julie, Howell, Sacha, McDiarmid, Sarah, Sellers, Katharine, Gareth Evans, D. and Harvie, Michelle (2019) Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy. The Breast, 1-6. (doi:10.1016/j.breast.2019.02.006).

Record type: Article

Abstract

Aim In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. Methods Between May 2005 and January 2008, 523 patients enrolled into the Prospective Outcomes in Sporadic versus Hereditary breast cancer study entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy. Results Data from 380 patients were available. Mean (standard deviation [SD]) pre-treatment body mass index (BMI) was 26.3 [5.6] kg/m2; 30% women gained > 5% body weight during the study period. Lower BMI at diagnosis predicted greater subsequent post treatment weight gain (4.3% relative weight gain for those in the 1st quartile of BMI compared to 0.8% for those in the 4th quartile; r=-0.22; p<0.001). No link to chemotherapy regimens, cigarette smoking, previous parity or chemotherapy induced amenorrhoea was noted. A total of 44% of women had central obesity (post-treatment waist measurement of >88cm). Conclusions Almost a third of premenopausal patients receiving adjuvant chemotherapy for breast cancer will gain clinically significant weight and over 40% will have central obesity 12-months following diagnosis. A greater weight gain is predicted by lower pretreatment BMI.

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Manuscript Revised Gandhi A et al. b 2019 01 22 - Accepted Manuscript
Restricted to Repository staff only until 15 February 2020.
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Accepted/In Press date: 12 February 2019
e-pub ahead of print date: 15 February 2019
Published date: June 2019

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Local EPrints ID: 428406
URI: https://eprints.soton.ac.uk/id/eprint/428406
ISSN: 0960-9776
PURE UUID: 847b660d-dfea-46c5-8f28-5f89dc188dd4

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Date deposited: 22 Feb 2019 17:30
Last modified: 18 Mar 2019 17:30

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