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Is essential fatty acid interconversion an important source of PUFA in humans?

Is essential fatty acid interconversion an important source of PUFA in humans?
Is essential fatty acid interconversion an important source of PUFA in humans?
Humans can obtain preformed long chain polyunsaturated fatty acids (PUFA) from the diet, but are also able to convert essential fatty acids (EFAs) to longer chain PUFA. The metabolic pathway responsible for EFA interconversion involves alternating desaturation and carbon chain elongation reactions, and carbon chain shortening by peroxisomal β-oxidation. Studies using stable isotope tracers or diets supplemented with EFAs show that capacity for PUFA synthesis is limited in humans such that docosahexaenoic acid (22:6n-3) synthesis in men is negligible. PUFA synthesis is greater in women of reproductive age than men. However, the magnitude of the contribution of hepatic PUFA synthesis to whole body PUFA status remains unclear. A number of extra-hepatic tissues have been shown to synthesise PUFA or to express genes for enzymes involved in this pathway. The precise function of extra-hepatic PUFA synthesis is largely unknown, although in T lymphocytes PUFA synthesis is involved in the regulation of cell activation and proliferation. Local PUFA synthesis may also be important for spermatogenesis and fertility. One possible role of extra-hepatic PUFA synthesis is that it may provide PUFA in a timely manner to facilitate specific cell functions. If so, this may suggest novel insights into the effect of dietary PUFA and / or polymorphisms in genes involved in PUFA synthesis on health and tissue function.
Desaturase , fatty acid, lymphocyte;, Elongase, polyunsaturated fatty acid, biosynthesis
0007-1145
615-624
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159

Burdge, Graham (2019) Is essential fatty acid interconversion an important source of PUFA in humans? British Journal of Nutrition, 121 (6), 615-624. (doi:10.1017/S0007114518003707).

Record type: Article

Abstract

Humans can obtain preformed long chain polyunsaturated fatty acids (PUFA) from the diet, but are also able to convert essential fatty acids (EFAs) to longer chain PUFA. The metabolic pathway responsible for EFA interconversion involves alternating desaturation and carbon chain elongation reactions, and carbon chain shortening by peroxisomal β-oxidation. Studies using stable isotope tracers or diets supplemented with EFAs show that capacity for PUFA synthesis is limited in humans such that docosahexaenoic acid (22:6n-3) synthesis in men is negligible. PUFA synthesis is greater in women of reproductive age than men. However, the magnitude of the contribution of hepatic PUFA synthesis to whole body PUFA status remains unclear. A number of extra-hepatic tissues have been shown to synthesise PUFA or to express genes for enzymes involved in this pathway. The precise function of extra-hepatic PUFA synthesis is largely unknown, although in T lymphocytes PUFA synthesis is involved in the regulation of cell activation and proliferation. Local PUFA synthesis may also be important for spermatogenesis and fertility. One possible role of extra-hepatic PUFA synthesis is that it may provide PUFA in a timely manner to facilitate specific cell functions. If so, this may suggest novel insights into the effect of dietary PUFA and / or polymorphisms in genes involved in PUFA synthesis on health and tissue function.

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Restricted to Repository staff only until 28 August 2019.
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More information

Accepted/In Press date: 27 December 2018
e-pub ahead of print date: 28 February 2019
Published date: 28 March 2019
Keywords: Desaturase , fatty acid, lymphocyte;, Elongase, polyunsaturated fatty acid, biosynthesis

Identifiers

Local EPrints ID: 428606
URI: https://eprints.soton.ac.uk/id/eprint/428606
ISSN: 0007-1145
PURE UUID: db69cf82-deff-441b-b821-4bde105225b0
ORCID for Graham Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 04 Mar 2019 17:30
Last modified: 13 Apr 2019 00:37

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