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Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge
Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie-restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3-5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch-up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life.
Bone, Intrauterine programming, Maternal nutrition, Low protein.
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
DuPriest, Elizabeth
48565943-c148-45ae-aa8b-f9e6cb758122
Kupfer, Philipp
cd0d3b18-2f25-445a-9aad-022beedff581
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Bagby, Susan
52fc8045-5dae-4608-8287-c8e52f0623b8
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
DuPriest, Elizabeth
48565943-c148-45ae-aa8b-f9e6cb758122
Kupfer, Philipp
cd0d3b18-2f25-445a-9aad-022beedff581
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Bagby, Susan
52fc8045-5dae-4608-8287-c8e52f0623b8
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Lanham, Stuart, DuPriest, Elizabeth, Kupfer, Philipp, Cooper, Cyrus, Bagby, Susan and Oreffo, Richard (2019) Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge. Physiological Reports. (In Press)

Record type: Article

Abstract

Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie-restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3-5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch-up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life.

Text
S Lanham Microswine paper Physio Reports clean - Accepted Manuscript
Restricted to Repository staff only until 1 July 2019.
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Accepted/In Press date: 1 April 2019
Keywords: Bone, Intrauterine programming, Maternal nutrition, Low protein.

Identifiers

Local EPrints ID: 429667
URI: https://eprints.soton.ac.uk/id/eprint/429667
PURE UUID: 0bc7ffdc-7cd2-44f8-97be-e14b64da9c6f
ORCID for Stuart Lanham: ORCID iD orcid.org/0000-0002-4516-264X
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 03 Apr 2019 16:30
Last modified: 04 Apr 2019 00:37

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Contributors

Author: Stuart Lanham ORCID iD
Author: Elizabeth DuPriest
Author: Philipp Kupfer
Author: Cyrus Cooper ORCID iD
Author: Susan Bagby
Author: Richard Oreffo ORCID iD

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