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Assessing the longitudinal stability of latent classes of substance use among gay, bisexual, and other men who have sex with men

Assessing the longitudinal stability of latent classes of substance use among gay, bisexual, and other men who have sex with men
Assessing the longitudinal stability of latent classes of substance use among gay, bisexual, and other men who have sex with men
Background Association between substance use and HIV-risk among gay and bisexual men (GBM) is well documented. However, their substance use patterns are diverse, and it is unknown whether self-reported use patterns are stable over time.Methods Sexually-active GBM, aged >16 years, were recruited in Metro Vancouver using respondent-driven sampling and followed across 5 study visits at six-month intervals (n = 449). To identify distinct patterns of substance use and their longitudinal stability, Latent Transition Analysis (LTA) was conducted for drugs reported by at least 30 participants. Intraclass correlation coefficients (ICC) quantified the stability of class assignments.Results Six classes characterizing ‘limited drug use’ (i.e., low use of all drugs, except alcohol), ‘conventional drug use’ (i.e., use of alcohol, marijuana, and tobacco), ‘club drug use’ (i.e., use of alcohol, cocaine, and psychedelics), ‘sex drug use’ (i.e., use of alcohol, crystal meth, GHB, poppers, and erectile dysfunction drugs), ‘street drug use’ (i.e., use of alcohol and street opioids) and ‘assorted drug use’ (i.e., use of most drugs) were identified. Across five visits (2.5 years), 26.3% (n = 118/449) of GBM transitioned between classes. The prevalence of limited use trended upwards (Baseline:24.5%, Visit 5:28.3%, p < 0.0001) and assorted use trended downwards (13.4%–9.6%, p = 0.001). All classes had strong longitudinal stability (ICC > 0.97).Conclusion The stability of latent substance use patterns highlight the utility of these measures in identifying patterns of substance use among people who use drugs – potentially allowing for better assessment of these groups and interventions related to their health.
0376-8716
348-355
Card, Kiffer G.
4bece098-5a9b-46cf-a64e-615f14acce73
Armstrong, Heather L.
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Carter, Allison
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Cui, Zishan
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Wang, Lu
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Zhu, Julia
ace0838d-a3a1-4594-a8ed-9ee5d94dfb26
Lachowsky, Nathan J.
87634bac-759c-4e7b-9f16-22fb37e87cf6
Moore, David M.
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Hogg, Robert S.
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Roth, Eric A.
4900d79c-ac00-475b-8bb9-e96243905ca7
Card, Kiffer G.
4bece098-5a9b-46cf-a64e-615f14acce73
Armstrong, Heather L.
3dc9c223-1a61-47ad-ab0b-50d06cddf4f2
Carter, Allison
173bd86a-9315-49f6-82d1-9c802142aba9
Cui, Zishan
298721d1-0246-4602-9120-c626eec8b142
Wang, Lu
2d470c09-6c10-481e-9133-7e7bcfe04706
Zhu, Julia
ace0838d-a3a1-4594-a8ed-9ee5d94dfb26
Lachowsky, Nathan J.
87634bac-759c-4e7b-9f16-22fb37e87cf6
Moore, David M.
b3bb7f8f-4409-412e-959b-bcda959a8d2d
Hogg, Robert S.
3f71ad69-9c8a-4732-bb86-4aa0652e1f3f
Roth, Eric A.
4900d79c-ac00-475b-8bb9-e96243905ca7

Card, Kiffer G., Armstrong, Heather L., Carter, Allison, Cui, Zishan, Wang, Lu, Zhu, Julia, Lachowsky, Nathan J., Moore, David M., Hogg, Robert S. and Roth, Eric A. (2018) Assessing the longitudinal stability of latent classes of substance use among gay, bisexual, and other men who have sex with men. Drug and Alcohol Dependence, 188, 348-355. (doi:10.1016/j.drugalcdep.2018.04.019).

Record type: Article

Abstract

Background Association between substance use and HIV-risk among gay and bisexual men (GBM) is well documented. However, their substance use patterns are diverse, and it is unknown whether self-reported use patterns are stable over time.Methods Sexually-active GBM, aged >16 years, were recruited in Metro Vancouver using respondent-driven sampling and followed across 5 study visits at six-month intervals (n = 449). To identify distinct patterns of substance use and their longitudinal stability, Latent Transition Analysis (LTA) was conducted for drugs reported by at least 30 participants. Intraclass correlation coefficients (ICC) quantified the stability of class assignments.Results Six classes characterizing ‘limited drug use’ (i.e., low use of all drugs, except alcohol), ‘conventional drug use’ (i.e., use of alcohol, marijuana, and tobacco), ‘club drug use’ (i.e., use of alcohol, cocaine, and psychedelics), ‘sex drug use’ (i.e., use of alcohol, crystal meth, GHB, poppers, and erectile dysfunction drugs), ‘street drug use’ (i.e., use of alcohol and street opioids) and ‘assorted drug use’ (i.e., use of most drugs) were identified. Across five visits (2.5 years), 26.3% (n = 118/449) of GBM transitioned between classes. The prevalence of limited use trended upwards (Baseline:24.5%, Visit 5:28.3%, p < 0.0001) and assorted use trended downwards (13.4%–9.6%, p = 0.001). All classes had strong longitudinal stability (ICC > 0.97).Conclusion The stability of latent substance use patterns highlight the utility of these measures in identifying patterns of substance use among people who use drugs – potentially allowing for better assessment of these groups and interventions related to their health.

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Substance use LTA (final submitted version) - Accepted Manuscript
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Accepted/In Press date: 9 April 2018
e-pub ahead of print date: 22 May 2018
Published date: 1 July 2018

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Local EPrints ID: 430035
URI: http://eprints.soton.ac.uk/id/eprint/430035
ISSN: 0376-8716
PURE UUID: 3e1ac633-ac53-4781-83fb-a318d8c3ca01
ORCID for Heather L. Armstrong: ORCID iD orcid.org/0000-0002-1071-8644

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Date deposited: 10 Apr 2019 16:30
Last modified: 20 Jul 2019 04:01

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Contributors

Author: Kiffer G. Card
Author: Allison Carter
Author: Zishan Cui
Author: Lu Wang
Author: Julia Zhu
Author: Nathan J. Lachowsky
Author: David M. Moore
Author: Robert S. Hogg
Author: Eric A. Roth

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