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Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years; the Children of SCOPE study

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years; the Children of SCOPE study
Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years; the Children of SCOPE study
Background: Maternal obesity has been implicated in the origins of childhood obesity through a sub-optimal environment in-utero.
Objective: We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity and plasma biomarkers of obesity, inflammation, insulin resistance and placental function with measures of childhood BMI and adiposity.

Methods: BMI z-score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), waist, arm and hip circumferences were measured in 1,173 6-year-old children of nulliparous pregnant women in the SCOPE study, New Zealand. Relationships of maternal early pregnancy (15 weeks’ gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment.

Results: 28.1% of mothers were overweight and 10.1% obese; compared with normal weight mothers, the BFP of their children were 5.3% higher [0.16 SD (95% CI 0.04 to 0.29) p=0.01] and 7.8% higher [0.27 (0.08 to 0.47) p=0.006] with comparable values for BMI z-score, arm, waist and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child’s SST, BMI z-score, hip circumference and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity.

Conclusion: In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity, similar associations were observed with PlGF which may imply a role for placenta function in the developmental programming of childhood obesity risk.
2047-6302
Dalrymple, Kathryn
d1e42b67-297a-473d-b3c1-cb275cf4cf64
Begum, Shahina
48250373-5ac0-4df5-b150-18e78b52905b
Thompson, John M.D.
09e63c7e-810a-4b9f-8732-2b412adda3be
Cutfield, Wayne
a01589bd-5b82-49fa-89e1-137e6f59e24d
Huang, Ying
4d003995-8ee9-4115-9778-a96bf1aa9a02
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Shelling, Andrew N.
a5ab6d31-e1e1-41a5-ac82-c7a8c2956ed2
Wall, Clare R.
e2d9fa85-ce60-4aaf-bcba-4c3d4600b5dc
North, Robyn
8e49c70d-2139-4764-9cb4-9fe7e4c4131f
McCowan, Lesley M.E.
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Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Mitchell, Edwin A.
00ddf519-bf0c-49a4-b257-a23179bc1e73
Dalrymple, Kathryn
d1e42b67-297a-473d-b3c1-cb275cf4cf64
Begum, Shahina
48250373-5ac0-4df5-b150-18e78b52905b
Thompson, John M.D.
09e63c7e-810a-4b9f-8732-2b412adda3be
Cutfield, Wayne
a01589bd-5b82-49fa-89e1-137e6f59e24d
Huang, Ying
4d003995-8ee9-4115-9778-a96bf1aa9a02
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Shelling, Andrew N.
a5ab6d31-e1e1-41a5-ac82-c7a8c2956ed2
Wall, Clare R.
e2d9fa85-ce60-4aaf-bcba-4c3d4600b5dc
North, Robyn
8e49c70d-2139-4764-9cb4-9fe7e4c4131f
McCowan, Lesley M.E.
02f6c766-b434-4396-858e-a84eaf34b62c
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Mitchell, Edwin A.
00ddf519-bf0c-49a4-b257-a23179bc1e73

Dalrymple, Kathryn, Begum, Shahina, Thompson, John M.D., Cutfield, Wayne, Huang, Ying, Seed, Paul T., Shelling, Andrew N., Wall, Clare R., North, Robyn, McCowan, Lesley M.E., Poston, Lucilla, Godfrey, Keith and Mitchell, Edwin A. (2019) Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years; the Children of SCOPE study. Pediatric Obesity. (In Press)

Record type: Article

Abstract

Background: Maternal obesity has been implicated in the origins of childhood obesity through a sub-optimal environment in-utero.
Objective: We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity and plasma biomarkers of obesity, inflammation, insulin resistance and placental function with measures of childhood BMI and adiposity.

Methods: BMI z-score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), waist, arm and hip circumferences were measured in 1,173 6-year-old children of nulliparous pregnant women in the SCOPE study, New Zealand. Relationships of maternal early pregnancy (15 weeks’ gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment.

Results: 28.1% of mothers were overweight and 10.1% obese; compared with normal weight mothers, the BFP of their children were 5.3% higher [0.16 SD (95% CI 0.04 to 0.29) p=0.01] and 7.8% higher [0.27 (0.08 to 0.47) p=0.006] with comparable values for BMI z-score, arm, waist and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child’s SST, BMI z-score, hip circumference and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity.

Conclusion: In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity, similar associations were observed with PlGF which may imply a role for placenta function in the developmental programming of childhood obesity risk.

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Accepted/In Press date: 18 March 2019

Identifiers

Local EPrints ID: 430260
URI: https://eprints.soton.ac.uk/id/eprint/430260
ISSN: 2047-6302
PURE UUID: 74b8f2bb-119d-4dfa-b875-f1de84220366
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 23 Apr 2019 16:30
Last modified: 10 May 2019 00:37

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