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Light-induced reversible DNA ligation of gold nanoparticle superlattices

Light-induced reversible DNA ligation of gold nanoparticle superlattices
Light-induced reversible DNA ligation of gold nanoparticle superlattices
DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. The oligonucleotides attached to the nanoparticles are encoded to ligate using 365 nm light, effectively locking the SLs and rendering them stable under DNA denaturing conditions. The reversible process of unlocking these structures is possible by irradiation with light at 315 nm, recovering the structures to their natural state. Our work inspires an alternative research direction toward postassembly manipulation of nanoparticle superstructures using external stimuli as a tool to enrich the library of additional material forms and their application in different media and environments.
1936-0851
5771-5777
Federica De Fazio, Angela
ea731ad3-9a83-4eed-bb1c-93ce801a7c13
El-Sagheer, Afaf H.
44c25cbd-405e-4e8f-aa12-443536a67f0d
Kahn, Jason S.
906af03d-a76f-411f-ad08-78aea85c0364
Nandhakumar, Iris S.
e9850fe5-1152-4df8-8a26-ed44b5564b04
Burton, Matthew
03c7134e-8b7b-469a-a8e2-807716d52e0c
Brown, Tom
f266635a-5a3c-4eed-ab58-ec9e1d2025c3
Muskens, Otto
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Gang, Oleg
0d3f0103-a3c4-4eb8-ae3c-073ae6c78532
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7
Federica De Fazio, Angela
ea731ad3-9a83-4eed-bb1c-93ce801a7c13
El-Sagheer, Afaf H.
44c25cbd-405e-4e8f-aa12-443536a67f0d
Kahn, Jason S.
906af03d-a76f-411f-ad08-78aea85c0364
Nandhakumar, Iris S.
e9850fe5-1152-4df8-8a26-ed44b5564b04
Burton, Matthew
03c7134e-8b7b-469a-a8e2-807716d52e0c
Brown, Tom
f266635a-5a3c-4eed-ab58-ec9e1d2025c3
Muskens, Otto
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Gang, Oleg
0d3f0103-a3c4-4eb8-ae3c-073ae6c78532
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7

Federica De Fazio, Angela, El-Sagheer, Afaf H., Kahn, Jason S., Nandhakumar, Iris S., Burton, Matthew, Brown, Tom, Muskens, Otto, Gang, Oleg and Kanaras, Antonios (2019) Light-induced reversible DNA ligation of gold nanoparticle superlattices. ACS Nano, 13 (5), 5771-5777. (doi:10.1021/acsnano.9b01294).

Record type: Article

Abstract

DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. The oligonucleotides attached to the nanoparticles are encoded to ligate using 365 nm light, effectively locking the SLs and rendering them stable under DNA denaturing conditions. The reversible process of unlocking these structures is possible by irradiation with light at 315 nm, recovering the structures to their natural state. Our work inspires an alternative research direction toward postassembly manipulation of nanoparticle superstructures using external stimuli as a tool to enrich the library of additional material forms and their application in different media and environments.

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More information

Accepted/In Press date: 1 April 2019
e-pub ahead of print date: 8 April 2019
Published date: 8 April 2019

Identifiers

Local EPrints ID: 430281
URI: https://eprints.soton.ac.uk/id/eprint/430281
ISSN: 1936-0851
PURE UUID: 66696459-7e70-47f4-aff0-ca124af62687
ORCID for Iris S. Nandhakumar: ORCID iD orcid.org/0000-0002-9668-9126
ORCID for Otto Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Antonios Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 24 Apr 2019 16:30
Last modified: 20 Jul 2019 01:13

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Contributors

Author: Angela Federica De Fazio
Author: Afaf H. El-Sagheer
Author: Jason S. Kahn
Author: Matthew Burton
Author: Tom Brown
Author: Otto Muskens ORCID iD
Author: Oleg Gang

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