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Combining pharmacological and nonpharmacological interventions in network meta-analysis in psychiatry

Combining pharmacological and nonpharmacological interventions in network meta-analysis in psychiatry
Combining pharmacological and nonpharmacological interventions in network meta-analysis in psychiatry
Network meta-analyses (NMAs) assess the comparative associations of 2 or more interventions even if they have not been compared in a randomized clinical trial.1 The validity of NMAs is founded on the assumption of transitivity (ie, that effect modifiers do not substantially differ across the included trials).1 The popularity of NMAs on pharmacological or nonpharmacological interventions is increasing in psychiatry.2 Recent NMAs have combined pharmacological and nonpharmacologic interventions in the same network. Although this may be informative for developing guidelines, it is methodologically challenging and could compromise the validity of NMAs. We aimed to evaluate NMAs that combined pharmacological and nonpharmacological interventions and provide guidance on how to conduct them.
2168-6238
Del Giovane, Cinzia
4800e7ef-0abe-42e8-9358-d6285af9c5ec
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Cipriani, Andrea
5f3097c8-4901-4a9b-b371-d17aeac9b686
Del Giovane, Cinzia
4800e7ef-0abe-42e8-9358-d6285af9c5ec
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Cipriani, Andrea
5f3097c8-4901-4a9b-b371-d17aeac9b686

Del Giovane, Cinzia, Cortese, Samuele and Cipriani, Andrea (2019) Combining pharmacological and nonpharmacological interventions in network meta-analysis in psychiatry. JAMA Psychiatry. (doi:10.1001/jamapsychiatry.2019.0574).

Record type: Letter

Abstract

Network meta-analyses (NMAs) assess the comparative associations of 2 or more interventions even if they have not been compared in a randomized clinical trial.1 The validity of NMAs is founded on the assumption of transitivity (ie, that effect modifiers do not substantially differ across the included trials).1 The popularity of NMAs on pharmacological or nonpharmacological interventions is increasing in psychiatry.2 Recent NMAs have combined pharmacological and nonpharmacologic interventions in the same network. Although this may be informative for developing guidelines, it is methodologically challenging and could compromise the validity of NMAs. We aimed to evaluate NMAs that combined pharmacological and nonpharmacological interventions and provide guidance on how to conduct them.

Text
DelGiovane_JAMAPsych_2019 - Accepted Manuscript
Restricted to Repository staff only until 17 April 2020.
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e-pub ahead of print date: 17 April 2019

Identifiers

Local EPrints ID: 430312
URI: https://eprints.soton.ac.uk/id/eprint/430312
ISSN: 2168-6238
PURE UUID: 9f59b852-94df-43a6-97cd-b4768dac4af5
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 25 Apr 2019 16:30
Last modified: 14 May 2019 00:29

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