The inheritance of cardiovascular disease risk
The inheritance of cardiovascular disease risk
Cardiovascular disease (CVD) is foremost among the non‐communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre‐existing conditions still accounting for nearly 25% of maternal deaths and is linked to gestational diabetes and pre‐eclampsia. Markers of CVD risk have been reported even in young children, related to prenatal factors such as mother's diet or body composition. The underlying mechanisms include epigenetic changes which can alter the trajectory of risk across the life course. Preventive interventions need to commence before conception, to reduce transmission of CVD risk by promoting healthy behaviours in prospective parents, as well as in pregnancy, and postpartum through breastfeeding and healthy complementary feeding. Surprisingly, these opportunities are not emphasised in the 2018 United Nations Political Declaration on NCDs. NCDs such as CVD have communicable risk components transmitted across generations by socio‐economic as well as biological factors, although the former can also become embodied in the offspring by epigenetic mechanisms. The inheritance of CVD risk, and social inequalities in such risk, thus raises wider questions about responsibility for the health of future generations at societal as well as individual levels.
1747-1756
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
October 2019
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Hanson, Mark
(2019)
The inheritance of cardiovascular disease risk.
Acta Paediatrica, 108 (10), .
(doi:10.1111/apa.14813).
Abstract
Cardiovascular disease (CVD) is foremost among the non‐communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre‐existing conditions still accounting for nearly 25% of maternal deaths and is linked to gestational diabetes and pre‐eclampsia. Markers of CVD risk have been reported even in young children, related to prenatal factors such as mother's diet or body composition. The underlying mechanisms include epigenetic changes which can alter the trajectory of risk across the life course. Preventive interventions need to commence before conception, to reduce transmission of CVD risk by promoting healthy behaviours in prospective parents, as well as in pregnancy, and postpartum through breastfeeding and healthy complementary feeding. Surprisingly, these opportunities are not emphasised in the 2018 United Nations Political Declaration on NCDs. NCDs such as CVD have communicable risk components transmitted across generations by socio‐economic as well as biological factors, although the former can also become embodied in the offspring by epigenetic mechanisms. The inheritance of CVD risk, and social inequalities in such risk, thus raises wider questions about responsibility for the health of future generations at societal as well as individual levels.
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Accepted/In Press date: 8 April 2019
e-pub ahead of print date: 9 April 2019
Published date: October 2019
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Local EPrints ID: 430511
URI: http://eprints.soton.ac.uk/id/eprint/430511
ISSN: 0803-5253
PURE UUID: 283d361c-abad-4538-9684-cec1506ae54a
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Date deposited: 02 May 2019 16:30
Last modified: 16 Mar 2024 07:47
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