Prenatal influences on bone health in children
Prenatal influences on bone health in children
Introduction: Optimising bone health might reduce the burden of both fractures in childhood and fragility fractures in later life. A number of maternal dietary and non-dietary factors have been identified that might influence offspring bone health and represent targets for intervention.
Areas covered: This article will outline the accrual of bone mineral throughout the life course and how observational and intervention studies have shown that maternal diet, in particular maternal calcium and 25-hydroxyvitamin D [25(OH)D] status, and lifestyle are associated with offspring bone mineralization. Studies examining the effects of maternal micronutrient supplementation on offspring bone mineral density (BMD) will also be discussed.
Expert commentary: There is a wealth of observational evidence relating maternal diet to offspring BMD. However, high quality randomized controlled trials, such as the ongoing MAVIDOS study, are needed before these findings can be definitively translated into public health advice.
193-202
Woolford, Stephen J.
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Cooper, Cyrus
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Harvey, Nicholas
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Moon, Rebecca J.
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Woolford, Stephen J.
a123d451-d086-45c0-a961-8704f5e90c90
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
Woolford, Stephen J., Cooper, Cyrus, Harvey, Nicholas and Moon, Rebecca J.
(2019)
Prenatal influences on bone health in children.
Expert Review of Endocrinology & Metabolism, 14 (3), .
(doi:10.1080/17446651.2019.1607727).
Abstract
Introduction: Optimising bone health might reduce the burden of both fractures in childhood and fragility fractures in later life. A number of maternal dietary and non-dietary factors have been identified that might influence offspring bone health and represent targets for intervention.
Areas covered: This article will outline the accrual of bone mineral throughout the life course and how observational and intervention studies have shown that maternal diet, in particular maternal calcium and 25-hydroxyvitamin D [25(OH)D] status, and lifestyle are associated with offspring bone mineralization. Studies examining the effects of maternal micronutrient supplementation on offspring bone mineral density (BMD) will also be discussed.
Expert commentary: There is a wealth of observational evidence relating maternal diet to offspring BMD. However, high quality randomized controlled trials, such as the ongoing MAVIDOS study, are needed before these findings can be definitively translated into public health advice.
Text
Prenatal influences on bone health in children revision no endnote codes
- Accepted Manuscript
More information
Accepted/In Press date: 11 April 2019
e-pub ahead of print date: 26 April 2019
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Local EPrints ID: 430644
URI: http://eprints.soton.ac.uk/id/eprint/430644
PURE UUID: 5660ccd8-0d34-4698-8160-6ff8ba3a7d3c
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Date deposited: 07 May 2019 16:30
Last modified: 18 Mar 2024 05:10
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Author:
Stephen J. Woolford
Author:
Rebecca J. Moon
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