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Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank

Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank
Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank
Dementia increases the risk of lower respiratory tract infection, but it is unclear whether risk varies across the normal range of cognitive ability. People with higher cognitive ability tend to behave in a healthier fashion as regards risk factors for lower respiratory tract infection and there is evidence that they have a lower risk of dying from respiratory disease as a whole. We therefore investigated the relationship between cognitive ability and mortality from lower respiratory tract infection. Participants were 434,413 people from UK Biobank (54% female). Cognitive ability was measured using tests of reaction time and reasoning. Data on deaths from lower respiratory infection were obtained from death certificates. Over a mean follow-up period of 6.99 years, 1,282 people died of lower respiratory infection. Mortality from lower respiratory tract infection fell as cognitive ability increased. For a standard deviation faster reaction time, the age- and sex-adjusted hazard ratio (95% confidence interval) was 0.80 (0.76, 0.83) and the multivariable-adjusted hazard ratio was 0.87 (0.83, 0.91). There were similar though weaker associations when cognitive ability was assessed using a reasoning test. These findings suggest that variation across the normal range of cognitive ability increase risk of dying from lower respiratory tract infection.
2045-2322
1-6
Gale, Catharine
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Batty, G. David
605ce199-493d-4238-b9c8-a2c076672e83
Gale, Catharine
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Batty, G. David
605ce199-493d-4238-b9c8-a2c076672e83

Gale, Catharine, Deary, Ian J. and Batty, G. David (2019) Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank. Scientific Reports, 9, 1-6, [1342]. (doi:10.1038/s41598-018-38126-w).

Record type: Article

Abstract

Dementia increases the risk of lower respiratory tract infection, but it is unclear whether risk varies across the normal range of cognitive ability. People with higher cognitive ability tend to behave in a healthier fashion as regards risk factors for lower respiratory tract infection and there is evidence that they have a lower risk of dying from respiratory disease as a whole. We therefore investigated the relationship between cognitive ability and mortality from lower respiratory tract infection. Participants were 434,413 people from UK Biobank (54% female). Cognitive ability was measured using tests of reaction time and reasoning. Data on deaths from lower respiratory infection were obtained from death certificates. Over a mean follow-up period of 6.99 years, 1,282 people died of lower respiratory infection. Mortality from lower respiratory tract infection fell as cognitive ability increased. For a standard deviation faster reaction time, the age- and sex-adjusted hazard ratio (95% confidence interval) was 0.80 (0.76, 0.83) and the multivariable-adjusted hazard ratio was 0.87 (0.83, 0.91). There were similar though weaker associations when cognitive ability was assessed using a reasoning test. These findings suggest that variation across the normal range of cognitive ability increase risk of dying from lower respiratory tract infection.

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More information

Accepted/In Press date: 18 December 2018
e-pub ahead of print date: 4 February 2019

Identifiers

Local EPrints ID: 430657
URI: http://eprints.soton.ac.uk/id/eprint/430657
ISSN: 2045-2322
PURE UUID: 2efc4fd4-110c-4d6a-a062-1bdba0104b4b
ORCID for Catharine Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 07 May 2019 16:30
Last modified: 16 Mar 2024 02:49

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Contributors

Author: Catharine Gale ORCID iD
Author: Ian J. Deary
Author: G. David Batty

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