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There is an individual tolerance to mechanical loading in compression induced deep tissue injury

There is an individual tolerance to mechanical loading in compression induced deep tissue injury
There is an individual tolerance to mechanical loading in compression induced deep tissue injury

Background: deep tissue injury is a type of pressure ulcer which originates subcutaneously due to sustained mechanical loading. The relationship between mechanical compression and damage development has been extensively studied in 2D. However, recent studies have suggested that damage develops beyond the site of indentation. The objective of this study was to compare mechanical loading conditions to the associated damage in 3D. 

Methods: an indentation test was performed on the tibialis anterior muscle of rats (n = 39). Changes in the form of oedema and structural damage were monitored with MRI in an extensive region. The internal deformations were evaluated using MRI based 3D finite element models. 

Findings: damage propagates away from the loaded region. The 3D analysis indicates that there is a subject specific tolerance to compression induced deep tissue injury. Interpretation: Individual tolerance is an important factor when considering the mechanical loading conditions which induce damage.

Deep tissue injury, Finite element analysis, Individual susceptibility, MRI, Pressure ulcers
0268-0033
153-160
Traa, Willeke A.
7133843c-25e6-456b-b472-a70e15ba9f28
van Turnhout, Mark C.
99444db0-dd4d-4bb1-9cd0-966eb9d5aba9
Nelissen, Jules L.
d7ade1c4-43ea-4331-b623-67d229300720
Strijkers, Gustav J.
c8506691-27fd-48f5-9ba9-174ba3feed28
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Oomens, Cees W.J.
b4884336-5230-4055-9df2-5400c1c57018
Traa, Willeke A.
7133843c-25e6-456b-b472-a70e15ba9f28
van Turnhout, Mark C.
99444db0-dd4d-4bb1-9cd0-966eb9d5aba9
Nelissen, Jules L.
d7ade1c4-43ea-4331-b623-67d229300720
Strijkers, Gustav J.
c8506691-27fd-48f5-9ba9-174ba3feed28
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Oomens, Cees W.J.
b4884336-5230-4055-9df2-5400c1c57018

Traa, Willeke A., van Turnhout, Mark C., Nelissen, Jules L., Strijkers, Gustav J., Bader, Dan L. and Oomens, Cees W.J. (2019) There is an individual tolerance to mechanical loading in compression induced deep tissue injury. Clinical Biomechanics, 63, 153-160. (doi:10.1016/j.clinbiomech.2019.02.015).

Record type: Article

Abstract

Background: deep tissue injury is a type of pressure ulcer which originates subcutaneously due to sustained mechanical loading. The relationship between mechanical compression and damage development has been extensively studied in 2D. However, recent studies have suggested that damage develops beyond the site of indentation. The objective of this study was to compare mechanical loading conditions to the associated damage in 3D. 

Methods: an indentation test was performed on the tibialis anterior muscle of rats (n = 39). Changes in the form of oedema and structural damage were monitored with MRI in an extensive region. The internal deformations were evaluated using MRI based 3D finite element models. 

Findings: damage propagates away from the loaded region. The 3D analysis indicates that there is a subject specific tolerance to compression induced deep tissue injury. Interpretation: Individual tolerance is an important factor when considering the mechanical loading conditions which induce damage.

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There is an individual tolerance to mechanical loading in compression induced deep tissue injury - Accepted Manuscript
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More information

Accepted/In Press date: 22 February 2019
e-pub ahead of print date: 23 February 2019
Published date: 1 March 2019
Keywords: Deep tissue injury, Finite element analysis, Individual susceptibility, MRI, Pressure ulcers

Identifiers

Local EPrints ID: 430835
URI: http://eprints.soton.ac.uk/id/eprint/430835
ISSN: 0268-0033
PURE UUID: 3e1069ee-9afa-4b6b-8759-ccb52c2142dd
ORCID for Dan L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

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Date deposited: 15 May 2019 16:30
Last modified: 07 Oct 2020 06:33

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Contributors

Author: Willeke A. Traa
Author: Mark C. van Turnhout
Author: Jules L. Nelissen
Author: Gustav J. Strijkers
Author: Dan L. Bader ORCID iD
Author: Cees W.J. Oomens

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