Cancer-related symptoms, mental well-being and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy
Cancer-related symptoms, mental well-being and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy
Purpose: There are known associations between treatment of prostate cancer (PCa) involving Androgen Deprivation Therapy (ADT) and psychological and physical side-effects. We investigate the associations between cancer-related symptoms, health-related quality of life (HRQL), and poor psychological outcomes in men whose treatment for PCa involved ADT.
Methods: A cross-sectional postal questionnaire was administered to UK men 18-42 months post diagnosis of PCa. Men completed items on functional outcomes using the Expanded Prostate Cancer Index Composite (EPIC-26), EuroQol-5D (EQ-5D), and the European Organisation for Research and Treatment of Cancer (EORTC) Fatigue subscale. Psychological outcomes (mental well-being and psychological distress) were assessed using the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) and the Kessler 6 item scale (K6) respectively. Associations between explanatory variables and psychological outcomes were assessed using stepped logistic regression.
Results: 13,097 men treated with ADT completed a questionnaire. A minority of men reported poor mental well-being (15.5%) or severe psychological distress (6.6%). After controlling for sociodemographic and clinical variables, reporting clinically significant fatigue was strongly associated with severe psychological distress (OR 9.92; 95% CI 7.63 to 12.89) and poor well-being (OR 3.86; 95% CI 3.38 to 4.42). All cancer-related symptoms and HRQL variables were associated with both psychological outcomes.
Conclusions: While the majority of men treated with ADT did not report poor psychological outcomes, a small proportion reported severe problems. Clinically significant fatigue was demonstrated as a possible indicator of poor outcomes. Healthcare systems need to have clear protocols in place which specifically and routinely target psychological distress and fatigue.
2741-2751
Wilding, Sarah
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Downing, Amy
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Wright, Penny
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Selby, Peter
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Watson, Eila
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Wagland, Richard
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Donnelly, David W.
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Hounsome, Luke
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Butcher, Hugh
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Mason, Malcolm D.
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Henry, Ann
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Gavin, Anna
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Glaser, Adam W.
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21 May 2019
Wilding, Sarah
a538ad99-f618-4022-9a21-cf063649f99d
Downing, Amy
f4ff289d-68c6-466b-bbc4-f920e10506b5
Wright, Penny
be58e744-69be-48f8-a416-8e543af1ad7b
Selby, Peter
4d78c7d9-9d7a-4d92-acf0-597c4168d757
Watson, Eila
d295228d-d534-4c35-844f-ca8471c169c0
Wagland, Richard
16a44dcc-29cd-4797-9af2-41ef87f64d08
Donnelly, David W.
3bbe4f83-23ee-46cc-aae3-2cb4c077dd05
Hounsome, Luke
07575bd0-d561-40fa-9680-5f5cdfb71508
Butcher, Hugh
ba20526e-5613-40e3-9659-df8d23c3bde3
Mason, Malcolm D.
a7a9b0dd-80b2-4a12-b760-f70d5728de63
Henry, Ann
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Gavin, Anna
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Glaser, Adam W.
9ce6cbd6-98e5-4dc3-a74c-91a9e45feb1c
Wilding, Sarah, Downing, Amy, Wright, Penny, Selby, Peter, Watson, Eila, Wagland, Richard, Donnelly, David W., Hounsome, Luke, Butcher, Hugh, Mason, Malcolm D., Henry, Ann, Gavin, Anna and Glaser, Adam W.
(2019)
Cancer-related symptoms, mental well-being and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy.
Quality of Life Research, 28, .
(doi:10.1007/s11136-019-02212-x).
Abstract
Purpose: There are known associations between treatment of prostate cancer (PCa) involving Androgen Deprivation Therapy (ADT) and psychological and physical side-effects. We investigate the associations between cancer-related symptoms, health-related quality of life (HRQL), and poor psychological outcomes in men whose treatment for PCa involved ADT.
Methods: A cross-sectional postal questionnaire was administered to UK men 18-42 months post diagnosis of PCa. Men completed items on functional outcomes using the Expanded Prostate Cancer Index Composite (EPIC-26), EuroQol-5D (EQ-5D), and the European Organisation for Research and Treatment of Cancer (EORTC) Fatigue subscale. Psychological outcomes (mental well-being and psychological distress) were assessed using the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) and the Kessler 6 item scale (K6) respectively. Associations between explanatory variables and psychological outcomes were assessed using stepped logistic regression.
Results: 13,097 men treated with ADT completed a questionnaire. A minority of men reported poor mental well-being (15.5%) or severe psychological distress (6.6%). After controlling for sociodemographic and clinical variables, reporting clinically significant fatigue was strongly associated with severe psychological distress (OR 9.92; 95% CI 7.63 to 12.89) and poor well-being (OR 3.86; 95% CI 3.38 to 4.42). All cancer-related symptoms and HRQL variables were associated with both psychological outcomes.
Conclusions: While the majority of men treated with ADT did not report poor psychological outcomes, a small proportion reported severe problems. Clinically significant fatigue was demonstrated as a possible indicator of poor outcomes. Healthcare systems need to have clear protocols in place which specifically and routinely target psychological distress and fatigue.
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Cancer-related symptoms, mental well-being and psychological distress in men diagnosed with prostate cancer treated with Androgen Deprivation Therapy
- Accepted Manuscript
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Wilding 2019 Article Cancer-related Symptoms Mental Well-being
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Accepted/In Press date: 11 May 2019
e-pub ahead of print date: 21 May 2019
Published date: 21 May 2019
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Local EPrints ID: 430966
URI: http://eprints.soton.ac.uk/id/eprint/430966
ISSN: 0962-9343
PURE UUID: fe8844c9-9982-45ca-ad6c-3e698884967c
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Date deposited: 20 May 2019 16:30
Last modified: 16 Mar 2024 07:51
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Contributors
Author:
Sarah Wilding
Author:
Amy Downing
Author:
Penny Wright
Author:
Peter Selby
Author:
Eila Watson
Author:
David W. Donnelly
Author:
Luke Hounsome
Author:
Hugh Butcher
Author:
Malcolm D. Mason
Author:
Ann Henry
Author:
Anna Gavin
Author:
Adam W. Glaser
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