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Recent advances in the molecular landscape of lung neuroendocrine tumors

Recent advances in the molecular landscape of lung neuroendocrine tumors
Recent advances in the molecular landscape of lung neuroendocrine tumors

Introduction: Neuroendocrine tumors of the lung (Lung-NETs) make up a heterogenous family of neoplasms showing neuroendocrine differentiation and encompass carcinoids and neuroendocrine carcinomas. On molecular grounds, they considered two completely distinct and separate tumor groups with no overlap of molecular alterations nor common developmental mechanisms. Areas covered: Two perspectives were evaluated based on an extensive review and rethinking of literature: (1) the current classification as an instrument to obtaining clinical and molecular insights into the context of Lung-NETs; and (2) an alternative and innovative interpretation of these tumors, proposing a tripartite separation into early aggressive primary high-grade neuroendocrine tumors (HGNET), differentiating or secondary HGNET, and indolent NET. Expert opinion: We herein provide an alternative outlook on Lung-NETs, which is a paradigm shift to current pathogenesis models and expands the understanding of these tumors.

carcinoma, copy number variation, evolution, gene, genomic analysis, Ki-67 index, lung, mutation, Neuroendocrine, pathogenesis, tumor
1473-7159
281-297
Pelosi, Giuseppe
ff759f2f-e348-46b2-bec5-da656ac574d9
Bianchi, Fabrizio
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Hofman, Paul
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Pattini, Linda
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Ströbel, Philipp
59dbcbf5-fc71-46b9-9b4f-69e534900de0
Calabrese, Fiorella
08cd91d4-31de-4e03-bdae-892f638a3775
Naheed, Salma
4128e70b-9f3a-49b1-9c1c-4fae82554c94
Holden, Chloe
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Cave, Judith
60c67e39-121a-49ca-8594-93e8e456464f
Bohnenberger, Hanibal
5fc7b35e-fe31-4524-a32a-ed19d2b2e4dd
Dinter, Helen
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Harari, Sergio
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Albini, Adriana
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Sonzogni, Angelica
bde05bc3-ad03-4590-bbe7-2fee0d8d1b0e
Papotti, Mauro
93592a03-6277-4ddb-aa05-ea99f642fee8
Volante, Marco
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Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Pelosi, Giuseppe
ff759f2f-e348-46b2-bec5-da656ac574d9
Bianchi, Fabrizio
b064d3bd-f0c0-4177-abf4-9801479be1e9
Hofman, Paul
9ccd36e7-c47e-4a7d-92d8-8beb4b6fb672
Pattini, Linda
28daa161-9608-4592-9319-61d9dd65cfa9
Ströbel, Philipp
59dbcbf5-fc71-46b9-9b4f-69e534900de0
Calabrese, Fiorella
08cd91d4-31de-4e03-bdae-892f638a3775
Naheed, Salma
4128e70b-9f3a-49b1-9c1c-4fae82554c94
Holden, Chloe
2a5d1641-3e7e-4537-96f0-1a3a011af340
Cave, Judith
60c67e39-121a-49ca-8594-93e8e456464f
Bohnenberger, Hanibal
5fc7b35e-fe31-4524-a32a-ed19d2b2e4dd
Dinter, Helen
44dc4d4b-bed3-48cc-a916-3867bf3690b3
Harari, Sergio
0f0e01ce-4508-4a19-896e-2ef1c35e98c7
Albini, Adriana
94c969f6-2e56-4418-b2de-cd253492c1bd
Sonzogni, Angelica
bde05bc3-ad03-4590-bbe7-2fee0d8d1b0e
Papotti, Mauro
93592a03-6277-4ddb-aa05-ea99f642fee8
Volante, Marco
244b2c87-842f-4216-8503-0558c9c7f656
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797

Pelosi, Giuseppe, Bianchi, Fabrizio, Hofman, Paul, Pattini, Linda, Ströbel, Philipp, Calabrese, Fiorella, Naheed, Salma, Holden, Chloe, Cave, Judith, Bohnenberger, Hanibal, Dinter, Helen, Harari, Sergio, Albini, Adriana, Sonzogni, Angelica, Papotti, Mauro, Volante, Marco and Ottensmeier, Christian H. (2019) Recent advances in the molecular landscape of lung neuroendocrine tumors. Expert Review of Molecular Diagnostics, 19 (4), 281-297. (doi:10.1080/14737159.2019.1595593).

Record type: Review

Abstract

Introduction: Neuroendocrine tumors of the lung (Lung-NETs) make up a heterogenous family of neoplasms showing neuroendocrine differentiation and encompass carcinoids and neuroendocrine carcinomas. On molecular grounds, they considered two completely distinct and separate tumor groups with no overlap of molecular alterations nor common developmental mechanisms. Areas covered: Two perspectives were evaluated based on an extensive review and rethinking of literature: (1) the current classification as an instrument to obtaining clinical and molecular insights into the context of Lung-NETs; and (2) an alternative and innovative interpretation of these tumors, proposing a tripartite separation into early aggressive primary high-grade neuroendocrine tumors (HGNET), differentiating or secondary HGNET, and indolent NET. Expert opinion: We herein provide an alternative outlook on Lung-NETs, which is a paradigm shift to current pathogenesis models and expands the understanding of these tumors.

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Recent adevances on the molecular landscape of lung NET- anonymous ERO-2018-0136.R2 - Accepted Manuscript
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Figure 1 Study design - Accepted Manuscript
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Figure 2 Natural history - Accepted Manuscript
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Figure 3 Histogenesis - Accepted Manuscript
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Figure 4 Histology - Accepted Manuscript
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Figure 5 Secondary HGNET with Ki67 - Accepted Manuscript
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Figure 6 INET - Accepted Manuscript
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More information

Accepted/In Press date: 12 March 2019
e-pub ahead of print date: 22 March 2019
Published date: 3 April 2019
Keywords: carcinoma, copy number variation, evolution, gene, genomic analysis, Ki-67 index, lung, mutation, Neuroendocrine, pathogenesis, tumor

Identifiers

Local EPrints ID: 431056
URI: http://eprints.soton.ac.uk/id/eprint/431056
ISSN: 1473-7159
PURE UUID: b9803339-61da-4936-87f6-16fa02b4a783

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Date deposited: 22 May 2019 16:30
Last modified: 07 Oct 2020 06:38

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Contributors

Author: Giuseppe Pelosi
Author: Fabrizio Bianchi
Author: Paul Hofman
Author: Linda Pattini
Author: Philipp Ströbel
Author: Fiorella Calabrese
Author: Salma Naheed
Author: Chloe Holden
Author: Judith Cave
Author: Hanibal Bohnenberger
Author: Helen Dinter
Author: Sergio Harari
Author: Adriana Albini
Author: Angelica Sonzogni
Author: Mauro Papotti
Author: Marco Volante

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