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Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study

Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study
Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study
AIMS/HYPOTHESIS:
The Pune Children's Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood.

METHODS:
We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detailed measurements at 8 years of age (glucose, insulin, HOMA-IR and other indices). Oral glucose tolerance, anthropometry, plasma lipids, BP, carotid intima-media thickness (IMT) and arterial pulse wave velocity (PWV) were measured at 21 years.

RESULTS:
Higher fasting glucose, insulin and HOMA-IR at 8 years predicted higher glucose, insulin, HOMA-IR, BP, lipids and IMT at 21 years. A 1 SD change in 8 year variables was associated with a 0.10-0.27 SD change at 21 years independently of obesity/adiposity at 8 years of age. A greater rise in glucose-insulin variables between 8 and 21 years was associated with higher cardiovascular risk factors, including PWV. Participants whose HOMA-IR measurement remained in the highest quartile (n = 31) had a more adverse cardiovascular risk profile compared with those whose HOMA-IR measurement remained in the lowest quartile (n = 28).

CONCLUSIONS/INTERPRETATION:
Prepubertal glucose-insulin metabolism is associated with adult cardiovascular risk and markers of atherosclerosis. Our results support interventions to improve glucose-insulin metabolism in childhood to reduce cardiovascular risk in later life.
0012-186X
1626-1636
Yajnik, C.S.
ea0648f2-b384-4e5c-9e0f-45cc852e0c75
Katre, Prachi
a336b256-0793-405a-89bc-6ed79c3a6212
Joshi, S.M.
d479292a-5ad7-408d-bcaf-d1a5f2c829f9
Kumaran, Kalyanaraman
de6f872c-7339-4a52-be84-e3bbae707744
Bhat, Dattatray S.
4dced0c4-126e-4dc2-aac2-f636bd466646
Lubree, Himangi
aa3fb2a8-81fb-4614-b136-3d04dfc3d85c
Memane, Nilam
7bf042cf-1764-428b-9a12-bb61b1074b64
Kinare, Arun S.
558ea0fd-7807-4c86-b6ab-d2465c24f8e4
Pandit, Anand N.
1f7497a8-c229-42bd-84bb-179b874483a5
Bhave, Sheila A.
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Bavdekar, Ashish
6d4da828-7878-4dd0-b688-3726fd5bd12c
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Yajnik, C.S.
ea0648f2-b384-4e5c-9e0f-45cc852e0c75
Katre, Prachi
a336b256-0793-405a-89bc-6ed79c3a6212
Joshi, S.M.
d479292a-5ad7-408d-bcaf-d1a5f2c829f9
Kumaran, Kalyanaraman
de6f872c-7339-4a52-be84-e3bbae707744
Bhat, Dattatray S.
4dced0c4-126e-4dc2-aac2-f636bd466646
Lubree, Himangi
aa3fb2a8-81fb-4614-b136-3d04dfc3d85c
Memane, Nilam
7bf042cf-1764-428b-9a12-bb61b1074b64
Kinare, Arun S.
558ea0fd-7807-4c86-b6ab-d2465c24f8e4
Pandit, Anand N.
1f7497a8-c229-42bd-84bb-179b874483a5
Bhave, Sheila A.
15b5d9ae-4a56-4d9a-a8fd-70353d8de978
Bavdekar, Ashish
6d4da828-7878-4dd0-b688-3726fd5bd12c
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18

Yajnik, C.S., Katre, Prachi, Joshi, S.M., Kumaran, Kalyanaraman, Bhat, Dattatray S., Lubree, Himangi, Memane, Nilam, Kinare, Arun S., Pandit, Anand N., Bhave, Sheila A., Bavdekar, Ashish and Fall, Caroline (2015) Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study. Diabetologia, 58 (7), 1626-1636. (doi:10.1007/s00125-015-3602-z).

Record type: Article

Abstract

AIMS/HYPOTHESIS:
The Pune Children's Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood.

METHODS:
We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detailed measurements at 8 years of age (glucose, insulin, HOMA-IR and other indices). Oral glucose tolerance, anthropometry, plasma lipids, BP, carotid intima-media thickness (IMT) and arterial pulse wave velocity (PWV) were measured at 21 years.

RESULTS:
Higher fasting glucose, insulin and HOMA-IR at 8 years predicted higher glucose, insulin, HOMA-IR, BP, lipids and IMT at 21 years. A 1 SD change in 8 year variables was associated with a 0.10-0.27 SD change at 21 years independently of obesity/adiposity at 8 years of age. A greater rise in glucose-insulin variables between 8 and 21 years was associated with higher cardiovascular risk factors, including PWV. Participants whose HOMA-IR measurement remained in the highest quartile (n = 31) had a more adverse cardiovascular risk profile compared with those whose HOMA-IR measurement remained in the lowest quartile (n = 28).

CONCLUSIONS/INTERPRETATION:
Prepubertal glucose-insulin metabolism is associated with adult cardiovascular risk and markers of atherosclerosis. Our results support interventions to improve glucose-insulin metabolism in childhood to reduce cardiovascular risk in later life.

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More information

Accepted/In Press date: 23 March 2015
e-pub ahead of print date: 5 May 2015
Published date: July 2015

Identifiers

Local EPrints ID: 431135
URI: http://eprints.soton.ac.uk/id/eprint/431135
ISSN: 0012-186X
PURE UUID: 7d892edf-06da-4a74-91f6-57177c4b8b3c
ORCID for Caroline Fall: ORCID iD orcid.org/0000-0003-4402-5552

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Date deposited: 24 May 2019 16:30
Last modified: 09 Jan 2022 02:38

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Contributors

Author: C.S. Yajnik
Author: Prachi Katre
Author: S.M. Joshi
Author: Dattatray S. Bhat
Author: Himangi Lubree
Author: Nilam Memane
Author: Arun S. Kinare
Author: Anand N. Pandit
Author: Sheila A. Bhave
Author: Ashish Bavdekar
Author: Caroline Fall ORCID iD

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