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Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease

Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease
Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease
Objective: To compare the sensitivity and specificity of objective cervical vestibular evoked myogenic potential (cVEMP) tuning curves and Electrocochleography (ECochG) for the diagnosis of Ménière’s disease (MD).

Design: Sensitivity and specificity were calculated from 95 % normative ranges of 500 Hz cVEMP threshold and ECochG SP/AP amplitude ratios.

Measures: extra-tympanic ECochG testing to 90 dB nHL clicks and cVEMP threshold tuning curves (250 to 1000 Hz).

Study sample: We tested 15 patients (30 ears) diagnosed with definite bilateral MD based on the clinical criteria proposed by the American Academy of Otolaryngology Head and Neck surgery, 1995 (assumed gold standard) and 20 controls.

Results: 500 Hz cVEMP threshold was the most promising parameter to differentiate MD ears from controls. cVEMP and ECochG showed high specificity (83.3 % and 100 %, respectively) and low to moderate sensitivity (22.2 % and 71.4 %) for long term MD. ECochG sensitivity increased to 89 % during a symptomatic period, compared to 33 % for cVEMP. However, ECochG can be difficult to schedule during symptomatic periods. Sensitivity of cVEMP for the diagnosis of MD appears limited.

Conclusions: ECochG has higher sensitivity than cVEMP in the diagnosis of Ménière’s patients, but the ECochG SP/AP amplitude ratio measure is not perfect for the diagnosis of MD.
1499-2027
Obeidat, Faten Saeed
41a0c78a-59e6-46c7-9a7e-fde736d10b27
Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a
Obeidat, Faten Saeed
41a0c78a-59e6-46c7-9a7e-fde736d10b27
Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a

Obeidat, Faten Saeed and Bell, Steven (2019) Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of Ménière’s disease. International Journal of Audiology. (doi:10.1080/14992027.2019.1627008).

Record type: Article

Abstract

Objective: To compare the sensitivity and specificity of objective cervical vestibular evoked myogenic potential (cVEMP) tuning curves and Electrocochleography (ECochG) for the diagnosis of Ménière’s disease (MD).

Design: Sensitivity and specificity were calculated from 95 % normative ranges of 500 Hz cVEMP threshold and ECochG SP/AP amplitude ratios.

Measures: extra-tympanic ECochG testing to 90 dB nHL clicks and cVEMP threshold tuning curves (250 to 1000 Hz).

Study sample: We tested 15 patients (30 ears) diagnosed with definite bilateral MD based on the clinical criteria proposed by the American Academy of Otolaryngology Head and Neck surgery, 1995 (assumed gold standard) and 20 controls.

Results: 500 Hz cVEMP threshold was the most promising parameter to differentiate MD ears from controls. cVEMP and ECochG showed high specificity (83.3 % and 100 %, respectively) and low to moderate sensitivity (22.2 % and 71.4 %) for long term MD. ECochG sensitivity increased to 89 % during a symptomatic period, compared to 33 % for cVEMP. However, ECochG can be difficult to schedule during symptomatic periods. Sensitivity of cVEMP for the diagnosis of MD appears limited.

Conclusions: ECochG has higher sensitivity than cVEMP in the diagnosis of Ménière’s patients, but the ECochG SP/AP amplitude ratio measure is not perfect for the diagnosis of MD.

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Revised_Manuscript 16 5 2019 - Author's Original
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14992027.2019.1627008 - Accepted Manuscript
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More information

Submitted date: 23 November 2018
Accepted/In Press date: 21 May 2019
Published date: 17 June 2019

Identifiers

Local EPrints ID: 432083
URI: http://eprints.soton.ac.uk/id/eprint/432083
ISSN: 1499-2027
PURE UUID: 3498d08a-e883-47e5-b356-4e0c81505ed7

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Date deposited: 01 Jul 2019 16:30
Last modified: 25 Nov 2021 21:23

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Contributors

Author: Faten Saeed Obeidat
Author: Steven Bell

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