The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The impact of BMI and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data.

The impact of BMI and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data.
The impact of BMI and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data.
Objective:
The aim of this study was to assess the association of body mass index (BMI) and smoking with risk of revision following total knee replacement (TKR) and total hip replacement (THR).

Design:
Primary care data, from the Clinical Practice Research Datalink (CPRD), was linked to inpatient hospital records, from Hospital Episode Statistics Admitted Patient Care (HES APC), and covered 1997 to 2014. Parametric survival models, with BMI and smoking status included as explanatory variables, were estimated for 10-year risk of revision and mortality, and were extrapolated to estimate lifetime risk of revision.

Findings:
TKR and THR cohorts included 10,260 and 10,961 individuals, respectively. For a change in BMI from 25 to 35, the 10-year risk of revision is expected change from 4.6% (3.3–6.4%) to 3.7% (2.6–5.1%) for TKR and 3.7% (2.8–5.1%) to 4.0% (2.8–5.7%) for THR for an otherwise average patient profile. Meanwhile, changing from a non-smoker to a current smoker is expected to change the risk of revision from 4.1% (3.1–5.5%) to 2.8% (1.7–4.7%) for TKR and from 3.8% (2.8–5.3%) to 2.9% (1.9–4.7%) for THR for an otherwise average patient profile. Estimates of lifetime risk were also similar for different values of BMI or smoking status.

Conclusions:
Obesity and smoking do not appear to have a meaningful impact on the risk of revision following TKR and THR.
1063-4584
Burn, E.
0277b51a-3aa1-40f2-81fb-96c506587db6
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Murray, D.W.
fa0e1764-e600-42bd-937d-6d7e5d623bbc
Silman, A.
1ab1fc13-51f5-44c8-92f1-0bb32a5c5754
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Prieto-Alhambra, D.
051113cd-2da1-4e0d-aa4b-d7b1fe63cd12
Pinedo-Villanueva, R.
ec8ed49e-bf51-435b-a6ce-5a23da325b3c
Burn, E.
0277b51a-3aa1-40f2-81fb-96c506587db6
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Murray, D.W.
fa0e1764-e600-42bd-937d-6d7e5d623bbc
Silman, A.
1ab1fc13-51f5-44c8-92f1-0bb32a5c5754
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Prieto-Alhambra, D.
051113cd-2da1-4e0d-aa4b-d7b1fe63cd12
Pinedo-Villanueva, R.
ec8ed49e-bf51-435b-a6ce-5a23da325b3c

Burn, E., Edwards, C.J., Murray, D.W., Silman, A., Cooper, C., Arden, N.K., Prieto-Alhambra, D. and Pinedo-Villanueva, R. (2019) The impact of BMI and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data. Osteoarthritis and Cartilage. (doi:10.1016/j.joca.2019.05.012).

Record type: Article

Abstract

Objective:
The aim of this study was to assess the association of body mass index (BMI) and smoking with risk of revision following total knee replacement (TKR) and total hip replacement (THR).

Design:
Primary care data, from the Clinical Practice Research Datalink (CPRD), was linked to inpatient hospital records, from Hospital Episode Statistics Admitted Patient Care (HES APC), and covered 1997 to 2014. Parametric survival models, with BMI and smoking status included as explanatory variables, were estimated for 10-year risk of revision and mortality, and were extrapolated to estimate lifetime risk of revision.

Findings:
TKR and THR cohorts included 10,260 and 10,961 individuals, respectively. For a change in BMI from 25 to 35, the 10-year risk of revision is expected change from 4.6% (3.3–6.4%) to 3.7% (2.6–5.1%) for TKR and 3.7% (2.8–5.1%) to 4.0% (2.8–5.7%) for THR for an otherwise average patient profile. Meanwhile, changing from a non-smoker to a current smoker is expected to change the risk of revision from 4.1% (3.1–5.5%) to 2.8% (1.7–4.7%) for TKR and from 3.8% (2.8–5.3%) to 2.9% (1.9–4.7%) for THR for an otherwise average patient profile. Estimates of lifetime risk were also similar for different values of BMI or smoking status.

Conclusions:
Obesity and smoking do not appear to have a meaningful impact on the risk of revision following TKR and THR.

Text
paper 10_05 clean - Accepted Manuscript
Download (92kB)
Text
Appendix 10_05
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 22 May 2019
e-pub ahead of print date: 30 May 2019

Identifiers

Local EPrints ID: 432352
URI: http://eprints.soton.ac.uk/id/eprint/432352
ISSN: 1063-4584
PURE UUID: 621f382d-bdb3-4697-9b35-c6a79ac9a59c
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 11 Jul 2019 16:30
Last modified: 26 Nov 2021 06:13

Export record

Altmetrics

Contributors

Author: E. Burn
Author: C.J. Edwards
Author: D.W. Murray
Author: A. Silman
Author: C. Cooper ORCID iD
Author: N.K. Arden
Author: D. Prieto-Alhambra
Author: R. Pinedo-Villanueva

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×