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Fracture prediction, imaging and screening in osteoporosis

Fracture prediction, imaging and screening in osteoporosis
Fracture prediction, imaging and screening in osteoporosis

Osteoporosis is associated with increased fragility of bone and a subsequent increased risk of fracture. The diagnosis of osteoporosis is intimately linked with the imaging and quantification of bone and BMD. Scanning modalities, such as dual-energy X-ray absorptiometry or quantitative CT, have been developed and honed over the past half century to provide measures of BMD and bone microarchitecture for the purposes of clinical practice and research. Combined with fracture prediction tools such as Fracture Risk Assessment Tool (FRAX) (which use a combination of clinical risk factors for fracture to provide a measure of risk), these elements have led to a paradigm shift in the ability to diagnose osteoporosis and predict individuals who are at risk of fragility fracture. Despite these developments, a treatment gap exists between individuals who are at risk of osteoporotic fracture and those who are receiving therapy. In this Review, we summarize the epidemiology of osteoporosis, the history of scanning modalities, fracture prediction tools and future directions, including the most recent developments in prediction of fractures.

1759-5029
Fuggle, Nicholas R.
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Curtis, Elizabeth M.
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Ward, Kate A.
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Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Fuggle, Nicholas R.
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Curtis, Elizabeth M.
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Ward, Kate A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Fuggle, Nicholas R., Curtis, Elizabeth M., Ward, Kate A., Harvey, Nicholas C., Dennison, Elaine M. and Cooper, Cyrus (2019) Fracture prediction, imaging and screening in osteoporosis. Nature Reviews Endocrinology. (doi:10.1038/s41574-019-0220-8).

Record type: Review

Abstract

Osteoporosis is associated with increased fragility of bone and a subsequent increased risk of fracture. The diagnosis of osteoporosis is intimately linked with the imaging and quantification of bone and BMD. Scanning modalities, such as dual-energy X-ray absorptiometry or quantitative CT, have been developed and honed over the past half century to provide measures of BMD and bone microarchitecture for the purposes of clinical practice and research. Combined with fracture prediction tools such as Fracture Risk Assessment Tool (FRAX) (which use a combination of clinical risk factors for fracture to provide a measure of risk), these elements have led to a paradigm shift in the ability to diagnose osteoporosis and predict individuals who are at risk of fragility fracture. Despite these developments, a treatment gap exists between individuals who are at risk of osteoporotic fracture and those who are receiving therapy. In this Review, we summarize the epidemiology of osteoporosis, the history of scanning modalities, fracture prediction tools and future directions, including the most recent developments in prediction of fractures.

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NREND-18-130_Cooper_v2_clean_1551975024_2_NRF - Accepted Manuscript
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Accepted/In Press date: 1 June 2019
Published date: 12 June 2019

Identifiers

Local EPrints ID: 432372
URI: http://eprints.soton.ac.uk/id/eprint/432372
ISSN: 1759-5029
PURE UUID: 71d01101-bb3e-4eeb-ac59-acd100f082bc
ORCID for Elizabeth M. Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Kate A. Ward: ORCID iD orcid.org/0000-0001-7034-6750
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Elaine M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 11 Jul 2019 16:30
Last modified: 26 Nov 2021 07:19

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