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Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO

Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO
Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO
Objectives: Minerals deficiencies during pregnancy have been shown to be associated with poorer cognitive outcomes in offspring. This study aimed to investigate associations of maternal plasma zinc and magnesium concentrations with cognitive development in 4-year old children from the Growing Up in Singapore Towards healthy Outcome cohort.

Methods: Maternal plasma zinc and magnesium concentrations were measured at 26–28 weeks’ gestation. The Lollipop test of school readiness, tests of working memory, number knowledge, receptive vocabulary, and phonological awareness were performed in children at 4 years. Associations were examined in 715 mother-offspring pairs using linear regressions adjusted for key confounders.

Results: Maternal plasma zinc and magnesium concentrations were 812 ± 144 µg/L and 19.9 ± 1.8 mg/L (mean±SD); 19% and 71% of mothers were zinc deficient and magnesium insufficient, respectively. After adjustment for multiple testing, higher maternal zinc concentrations (per SD increment) were associated with 0.35 higher scores in Lollipop subtest 2 of picture description and spatial identification (95% CI: 0.13, 0.58); higher maternal magnesium concentrations (per SD increment) were associated with 0.65 higher scores in Lollipop subtest 4 of letters and writing identification (95% CI: 0.23, 1.07).

Discussion: No significant associations were observed for other tests, suggesting little long term influences of maternal zinc and magnesium on child's cognitive development.
1028-415X
Lai, Jun S.
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Cai, Shirong
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Feng, Lei
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Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Yap, Fabian
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Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chong, Yap-Seng
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Godfrey, Keith
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Meaney, Michael J.
5c6db45a-1f5b-4e1f-8c0b-07a8f7b29f66
Rifkin-Graboi, Anne
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Broekman, Birit F.P.
c8933c70-c439-4676-9d4d-2c522f193589
Chong, Mary Foong-Fong
1e188259-b1ab-4448-9e65-5b6a0fd99502
Lai, Jun S.
1fd69464-147f-4220-ab67-f9d76437cf3b
Cai, Shirong
0d23d2c5-889d-4f33-887f-b52e3d341ba4
Feng, Lei
03eb8d20-3450-45d0-9fac-486f826905e6
Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Meaney, Michael J.
5c6db45a-1f5b-4e1f-8c0b-07a8f7b29f66
Rifkin-Graboi, Anne
af440bed-c49d-4417-93b3-2243c8a2f1a8
Broekman, Birit F.P.
c8933c70-c439-4676-9d4d-2c522f193589
Chong, Mary Foong-Fong
1e188259-b1ab-4448-9e65-5b6a0fd99502

Lai, Jun S., Cai, Shirong, Feng, Lei, Shek, Lynette P., Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Godfrey, Keith, Meaney, Michael J., Rifkin-Graboi, Anne, Broekman, Birit F.P. and Chong, Mary Foong-Fong (2019) Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO. Nutritional Neuroscience. (doi:10.1080/1028415X.2019.1643624).

Record type: Article

Abstract

Objectives: Minerals deficiencies during pregnancy have been shown to be associated with poorer cognitive outcomes in offspring. This study aimed to investigate associations of maternal plasma zinc and magnesium concentrations with cognitive development in 4-year old children from the Growing Up in Singapore Towards healthy Outcome cohort.

Methods: Maternal plasma zinc and magnesium concentrations were measured at 26–28 weeks’ gestation. The Lollipop test of school readiness, tests of working memory, number knowledge, receptive vocabulary, and phonological awareness were performed in children at 4 years. Associations were examined in 715 mother-offspring pairs using linear regressions adjusted for key confounders.

Results: Maternal plasma zinc and magnesium concentrations were 812 ± 144 µg/L and 19.9 ± 1.8 mg/L (mean±SD); 19% and 71% of mothers were zinc deficient and magnesium insufficient, respectively. After adjustment for multiple testing, higher maternal zinc concentrations (per SD increment) were associated with 0.35 higher scores in Lollipop subtest 2 of picture description and spatial identification (95% CI: 0.13, 0.58); higher maternal magnesium concentrations (per SD increment) were associated with 0.65 higher scores in Lollipop subtest 4 of letters and writing identification (95% CI: 0.23, 1.07).

Discussion: No significant associations were observed for other tests, suggesting little long term influences of maternal zinc and magnesium on child's cognitive development.

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Accepted/In Press date: 1 July 2019
e-pub ahead of print date: 22 July 2019

Identifiers

Local EPrints ID: 433158
URI: http://eprints.soton.ac.uk/id/eprint/433158
ISSN: 1028-415X
PURE UUID: fcc81bc2-c8be-4ad5-868a-51c17a2e89e9
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 09 Aug 2019 16:30
Last modified: 26 Nov 2021 05:53

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Contributors

Author: Jun S. Lai
Author: Shirong Cai
Author: Lei Feng
Author: Lynette P. Shek
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap-Seng Chong
Author: Keith Godfrey ORCID iD
Author: Michael J. Meaney
Author: Anne Rifkin-Graboi
Author: Birit F.P. Broekman
Author: Mary Foong-Fong Chong

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