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Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with Rheumatoid Arthritis

Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with Rheumatoid Arthritis
Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with Rheumatoid Arthritis
Intake of blue mussels decreased disease activity in women with rheumatoid arthritis (RA) in the randomized cross-over MIRA (Mussels, inflammation and RA) trial. This study investigates potential causes of the decreased disease activity by analysing fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in the participants of the MIRA trial. Twenty-three women completed the randomized 2 × 11-week cross-over dietary intervention, exchanging one cooked meal per day, five days a week, with a meal including 75 g blue mussels or 75 g meat. Fatty acid composition in erythrocytes and plasma and 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomics data were analysed with multivariate data analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) and OPLS with effect projections (OPLS-EP) were performed to compare the two diets. The fatty acid profile in erythrocytes was different after intake of blue mussels compared to the control diet, and all samples were correctly classified to either the blue mussel diet or control diet. Changes following blue mussel intake included significant increases in omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at the group level but not for all individuals. The fatty acid profile in plasma phospholipids and 1H-NMR serum metabolites did not differ significantly between the diets. To conclude, modelling fatty acids in erythrocytes may be a better biomarker for seafood intake than only EPA and DHA content. The change in fatty acid pattern in erythrocytes could be related to reduction in disease activity, although it cannot be excluded that other factors than omega-3 fatty acids potentiate the effect.
0952-3278
7-15
Lindqvist, Helen M.
30ee27c8-a254-43ad-bce1-fc2ac8c04e38
Gjertsson, Inger
70af3a18-55db-4a52-8ff9-f282143cbdf0
Andersson, Sofia
efab85ef-2f89-4a38-87f0-1c4038113f21
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Bärebring, Linnea
2d80bd54-8a1a-4368-9bbf-a7d9e228a060
Lindqvist, Helen M.
30ee27c8-a254-43ad-bce1-fc2ac8c04e38
Gjertsson, Inger
70af3a18-55db-4a52-8ff9-f282143cbdf0
Andersson, Sofia
efab85ef-2f89-4a38-87f0-1c4038113f21
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Bärebring, Linnea
2d80bd54-8a1a-4368-9bbf-a7d9e228a060

Lindqvist, Helen M., Gjertsson, Inger, Andersson, Sofia, Calder, Philip and Bärebring, Linnea (2019) Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with Rheumatoid Arthritis. Prostaglandins, Leukotrienes and Essential Fatty Acids, 150, 7-15. (doi:10.1016/j.plefa.2019.08.004).

Record type: Article

Abstract

Intake of blue mussels decreased disease activity in women with rheumatoid arthritis (RA) in the randomized cross-over MIRA (Mussels, inflammation and RA) trial. This study investigates potential causes of the decreased disease activity by analysing fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in the participants of the MIRA trial. Twenty-three women completed the randomized 2 × 11-week cross-over dietary intervention, exchanging one cooked meal per day, five days a week, with a meal including 75 g blue mussels or 75 g meat. Fatty acid composition in erythrocytes and plasma and 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomics data were analysed with multivariate data analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) and OPLS with effect projections (OPLS-EP) were performed to compare the two diets. The fatty acid profile in erythrocytes was different after intake of blue mussels compared to the control diet, and all samples were correctly classified to either the blue mussel diet or control diet. Changes following blue mussel intake included significant increases in omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at the group level but not for all individuals. The fatty acid profile in plasma phospholipids and 1H-NMR serum metabolites did not differ significantly between the diets. To conclude, modelling fatty acids in erythrocytes may be a better biomarker for seafood intake than only EPA and DHA content. The change in fatty acid pattern in erythrocytes could be related to reduction in disease activity, although it cannot be excluded that other factors than omega-3 fatty acids potentiate the effect.

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MIRA manuscript 2 190820 - Accepted Manuscript
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MIRA Abstract 190821 - Accepted Manuscript
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More information

Accepted/In Press date: 23 August 2019
e-pub ahead of print date: 24 August 2019
Published date: 24 August 2019

Identifiers

Local EPrints ID: 433691
URI: http://eprints.soton.ac.uk/id/eprint/433691
ISSN: 0952-3278
PURE UUID: 2cb1a7d6-186b-4462-898e-ef33221fcd26
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 30 Aug 2019 16:30
Last modified: 22 Nov 2021 07:38

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Contributors

Author: Helen M. Lindqvist
Author: Inger Gjertsson
Author: Sofia Andersson
Author: Philip Calder ORCID iD
Author: Linnea Bärebring

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