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Particulate matter and the airway epithelium – the special case of the underground?

Particulate matter and the airway epithelium – the special case of the underground?
Particulate matter and the airway epithelium – the special case of the underground?
Airborne particulate matter (PM) is a leading driver of premature mortality and cardiopulmonary morbidity, associated with exacerbations of asthma and chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. The airway epithelium, as the principal site of PM deposition, is critical to the effects of, and initial response to, PM. A key mechanism by which PM exerts its effects is the generation of reactive oxygen species (ROS), inducing antioxidant and inflammatory responses in exposed epithelial cells. However, much of what is known about the effects of PM is based on research using particulates from urban air. PM from underground railways is compositionally highly distinct from urban PM, being rich in metals associated with wheel, rail, and brake wear and electrical arcing and component wear, which endows underground PM with potent ROS-generating capacity. Underground PM also appears to be more inflammogenic than urban PM in epithelial cells, but there is a lack of research into effects on exposed individuals, especially those with underlying health conditions. This review summarises current knowledge about the effects of PM on the airway epithelium, how the effects of underground PM may be different to urban PM, and the potential health consequences and mitigation strategies for commuters and workers in underground railways.
0905-9180
Cooper, Dawn, Marie
c6d9a1f0-7eef-493d-a0ee-c52efa3b28fb
Loxham, Matthew
8ef02171-9040-4c1d-8452-2ca34c56facb
Cooper, Dawn, Marie
c6d9a1f0-7eef-493d-a0ee-c52efa3b28fb
Loxham, Matthew
8ef02171-9040-4c1d-8452-2ca34c56facb

Cooper, Dawn, Marie and Loxham, Matthew (2019) Particulate matter and the airway epithelium – the special case of the underground? European Respiratory Review, 28 (153), [190066]. (doi:10.1183/16000617.0066-2019).

Record type: Review

Abstract

Airborne particulate matter (PM) is a leading driver of premature mortality and cardiopulmonary morbidity, associated with exacerbations of asthma and chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. The airway epithelium, as the principal site of PM deposition, is critical to the effects of, and initial response to, PM. A key mechanism by which PM exerts its effects is the generation of reactive oxygen species (ROS), inducing antioxidant and inflammatory responses in exposed epithelial cells. However, much of what is known about the effects of PM is based on research using particulates from urban air. PM from underground railways is compositionally highly distinct from urban PM, being rich in metals associated with wheel, rail, and brake wear and electrical arcing and component wear, which endows underground PM with potent ROS-generating capacity. Underground PM also appears to be more inflammogenic than urban PM in epithelial cells, but there is a lack of research into effects on exposed individuals, especially those with underlying health conditions. This review summarises current knowledge about the effects of PM on the airway epithelium, how the effects of underground PM may be different to urban PM, and the potential health consequences and mitigation strategies for commuters and workers in underground railways.

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Accepted/In Press date: 23 August 2019
e-pub ahead of print date: 25 September 2019

Identifiers

Local EPrints ID: 433717
URI: http://eprints.soton.ac.uk/id/eprint/433717
ISSN: 0905-9180
PURE UUID: e92ee4f4-fb8f-439b-b13e-26e18cc3aeeb
ORCID for Dawn, Marie Cooper: ORCID iD orcid.org/0000-0001-9785-9820
ORCID for Matthew Loxham: ORCID iD orcid.org/0000-0001-6459-538X

Catalogue record

Date deposited: 02 Sep 2019 16:30
Last modified: 26 Nov 2021 03:11

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Contributors

Author: Dawn, Marie Cooper ORCID iD
Author: Matthew Loxham ORCID iD

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