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Association between quantitative sensory testing and pain or disability in paediatric and young adult chronic pain: protocol for a systematic review and meta-analysis

Association between quantitative sensory testing and pain or disability in paediatric and young adult chronic pain: protocol for a systematic review and meta-analysis
Association between quantitative sensory testing and pain or disability in paediatric and young adult chronic pain: protocol for a systematic review and meta-analysis
Introduction@ this protocol describes the objective and methods of a systematic review of the association between quantitative sensory testing (QST) measures and pain intensity or disability in paediatric chronic pain (PCP). The review will also assess whether the relationship strength is moderated by variables related to the QST method and pain condition; the use of QST in PCP (modalities, outcome measures and anatomical test sites as well as differentiating between pain mechanisms (e.g., neuropathic vs. nociceptive) and in selecting analgesics); the reliability of QST across the paediatric age range; the ability of QST to differentiate patients with chronic pain from healthy controls; and differences between anatomical test sites.

Methods and analysis: MEDLINE, PsycINFO , CINHAL, Web of Science, Scopus, Cochrane Library and OpenGrey will be searched. English language studies will be eligible if they; recruit a sample aged 6 to 24 (inclusive) with chronic pain, including primary and secondary pain; apply at least one of the following QST modalities: chemical, electrical, mechanical (sub-groups include pressure, punctate/brush, vibratory) or thermal stimulus, to measure perception of noxious or innocuous stimuli applied to skin, muscle or joint; use a testing protocol to control for stimulus properties: modality, anatomical site, intensity, duration, and sequence. Following title and abstract screening, the full texts of relevant records will be independently assessed by two reviewers. For eligible studies, one reviewer will extract study characteristics and data, and another will check for accuracy. Both will undertake independent quality assessments using Appraisal Tool for Cross Sectional Studies (AXIS). A qualitative synthesis will be presented with discussion centred around different QST modalities. Where eligible data permit, meta-analyses will be performed separately for different QST modalities using Comprehensive Meta-Analysis.

Ethics and dissemination: review findings will be reported in a peer-reviewed journal and presented at conferences. The study raises no ethical issues.
2044-6055
Schoth, Daniel
73f3036e-b8cb-40b2-9466-e8e0f341fdd5
Blankenburg, Markus
050675d0-47f8-4947-b221-1ab05e2ddc36
Wager, Julia
601fa8f0-a8b7-41e6-8664-42580820fc2b
Broadbent, Philippa, Katherine
aec0fc9c-f7b5-43d9-bb37-5acca6088d9b
Zhang, Jin
27009b1e-dd46-4a6c-a3bc-d5a90246d9e9
Zernikow, Boris
6a886835-ce98-4123-8339-8e080e136616
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558
Schoth, Daniel
73f3036e-b8cb-40b2-9466-e8e0f341fdd5
Blankenburg, Markus
050675d0-47f8-4947-b221-1ab05e2ddc36
Wager, Julia
601fa8f0-a8b7-41e6-8664-42580820fc2b
Broadbent, Philippa, Katherine
aec0fc9c-f7b5-43d9-bb37-5acca6088d9b
Zhang, Jin
27009b1e-dd46-4a6c-a3bc-d5a90246d9e9
Zernikow, Boris
6a886835-ce98-4123-8339-8e080e136616
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558

Schoth, Daniel, Blankenburg, Markus, Wager, Julia, Broadbent, Philippa, Katherine, Zhang, Jin, Zernikow, Boris and Liossi, Christina (2019) Association between quantitative sensory testing and pain or disability in paediatric and young adult chronic pain: protocol for a systematic review and meta-analysis. BMJ Open, 9 (10), [e031861]. (doi:10.1136/bmjopen-2019-031861).

Record type: Article

Abstract

Introduction@ this protocol describes the objective and methods of a systematic review of the association between quantitative sensory testing (QST) measures and pain intensity or disability in paediatric chronic pain (PCP). The review will also assess whether the relationship strength is moderated by variables related to the QST method and pain condition; the use of QST in PCP (modalities, outcome measures and anatomical test sites as well as differentiating between pain mechanisms (e.g., neuropathic vs. nociceptive) and in selecting analgesics); the reliability of QST across the paediatric age range; the ability of QST to differentiate patients with chronic pain from healthy controls; and differences between anatomical test sites.

Methods and analysis: MEDLINE, PsycINFO , CINHAL, Web of Science, Scopus, Cochrane Library and OpenGrey will be searched. English language studies will be eligible if they; recruit a sample aged 6 to 24 (inclusive) with chronic pain, including primary and secondary pain; apply at least one of the following QST modalities: chemical, electrical, mechanical (sub-groups include pressure, punctate/brush, vibratory) or thermal stimulus, to measure perception of noxious or innocuous stimuli applied to skin, muscle or joint; use a testing protocol to control for stimulus properties: modality, anatomical site, intensity, duration, and sequence. Following title and abstract screening, the full texts of relevant records will be independently assessed by two reviewers. For eligible studies, one reviewer will extract study characteristics and data, and another will check for accuracy. Both will undertake independent quality assessments using Appraisal Tool for Cross Sectional Studies (AXIS). A qualitative synthesis will be presented with discussion centred around different QST modalities. Where eligible data permit, meta-analyses will be performed separately for different QST modalities using Comprehensive Meta-Analysis.

Ethics and dissemination: review findings will be reported in a peer-reviewed journal and presented at conferences. The study raises no ethical issues.

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QST protocol 02-09-2019 Clean - Accepted Manuscript
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More information

Accepted/In Press date: 4 September 2019
e-pub ahead of print date: 7 October 2019

Identifiers

Local EPrints ID: 434031
URI: http://eprints.soton.ac.uk/id/eprint/434031
ISSN: 2044-6055
PURE UUID: 2c55303d-2a56-4305-bb95-e4e9925915d0
ORCID for Christina Liossi: ORCID iD orcid.org/0000-0003-0627-6377

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Date deposited: 11 Sep 2019 16:30
Last modified: 07 Oct 2020 01:52

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Contributors

Author: Daniel Schoth
Author: Markus Blankenburg
Author: Julia Wager
Author: Philippa, Katherine Broadbent
Author: Jin Zhang
Author: Boris Zernikow

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