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Diagnosis and treatment of biofilm infections in children

Diagnosis and treatment of biofilm infections in children
Diagnosis and treatment of biofilm infections in children

Purpose of review: biofilm-associated infections cause difficulties in the management of childhood chronic infections and other diseases, due to the invasive nature of interventions which are often necessary for definitive management. Despite their importance, there are challenges in diagnosing biofilm infections and gaps in clinicians' understanding regarding the significance of biofilms.

Recent findings: many chronic infections associated with biofilms remain difficult or impossible to eradicate with conventional therapy. Surgical intervention, implant removal or long-term intermittent or suppressive antimicrobial therapy may be required. There are still significant challenges in detecting biofilms which presents a barrier in clinical practice and research. Novel therapies to disrupt biofilms are currently under investigation, which may help reduce the impact of antimicrobial resistance.

Summary: biofilm-associated infection should be considered wherever there is clinical concern for an infection affecting prosthetic material, where there is a predisposing condition such as suppurative lung disease; or in the setting of chronic or relapsing infections which may be culture negative. New diagnostic methods for detecting biofilms are a research priority for both clinical diagnosis and the ability to conduct high quality clinical trials of novel antibiofilm interventions.

0951-7375
505-509
Munro, Alasdair P.S.
25d23d32-71d5-481f-ae63-303f1af3c552
Highmore, Callum J.
04809bd8-7cad-4dcf-b67d-264697f893b9
Webb, Jeremy S.
1ecadf17-c81c-48ae-b761-b2c1d03a5e89
Faust, Saul N.
f97df780-9f9b-418e-b349-7adf63e150c1
Munro, Alasdair P.S.
25d23d32-71d5-481f-ae63-303f1af3c552
Highmore, Callum J.
04809bd8-7cad-4dcf-b67d-264697f893b9
Webb, Jeremy S.
1ecadf17-c81c-48ae-b761-b2c1d03a5e89
Faust, Saul N.
f97df780-9f9b-418e-b349-7adf63e150c1

Munro, Alasdair P.S., Highmore, Callum J., Webb, Jeremy S. and Faust, Saul N. (2019) Diagnosis and treatment of biofilm infections in children. Current opinion in infectious diseases, 32 (5), 505-509. (doi:10.1097/QCO.0000000000000582).

Record type: Article

Abstract

Purpose of review: biofilm-associated infections cause difficulties in the management of childhood chronic infections and other diseases, due to the invasive nature of interventions which are often necessary for definitive management. Despite their importance, there are challenges in diagnosing biofilm infections and gaps in clinicians' understanding regarding the significance of biofilms.

Recent findings: many chronic infections associated with biofilms remain difficult or impossible to eradicate with conventional therapy. Surgical intervention, implant removal or long-term intermittent or suppressive antimicrobial therapy may be required. There are still significant challenges in detecting biofilms which presents a barrier in clinical practice and research. Novel therapies to disrupt biofilms are currently under investigation, which may help reduce the impact of antimicrobial resistance.

Summary: biofilm-associated infection should be considered wherever there is clinical concern for an infection affecting prosthetic material, where there is a predisposing condition such as suppurative lung disease; or in the setting of chronic or relapsing infections which may be culture negative. New diagnostic methods for detecting biofilms are a research priority for both clinical diagnosis and the ability to conduct high quality clinical trials of novel antibiofilm interventions.

Text
Final Paeds biofilm review CID - Accepted Manuscript
Restricted to Repository staff only until 1 October 2020.
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e-pub ahead of print date: 1 October 2019

Identifiers

Local EPrints ID: 434222
URI: https://eprints.soton.ac.uk/id/eprint/434222
ISSN: 0951-7375
PURE UUID: df12bf7f-02db-47d7-bfeb-c96c9e6b3913
ORCID for Saul N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 17 Sep 2019 16:30
Last modified: 14 Dec 2019 01:35

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