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Sensing the unreachable: challenges and opportunities in biofilm detection

Sensing the unreachable: challenges and opportunities in biofilm detection
Sensing the unreachable: challenges and opportunities in biofilm detection
Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corrosion, to drug resistant infections. Besides the challenges in control, biofilms are also difficult to detect due to the lack of biofilm-specific biomarkers and methods for non-destructive imaging. In this article, we present a concise review of recent advancements in this field, with a focus on medical device-associated infections. We also discuss the technologies that have potential for non-destructive detection of bacterial biofilms.
0958-1669
79-84
Xu, Yikang
f6c33bfb-d0ba-4b60-b151-b60c8b89056c
Dhaouadi, Yousr
e4130be2-9325-4865-940e-d643be54bc86
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Ren, Dacheng
99867fea-b187-4f48-be80-ee6854bc0d0c
Xu, Yikang
f6c33bfb-d0ba-4b60-b151-b60c8b89056c
Dhaouadi, Yousr
e4130be2-9325-4865-940e-d643be54bc86
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Ren, Dacheng
99867fea-b187-4f48-be80-ee6854bc0d0c

Xu, Yikang, Dhaouadi, Yousr, Stoodley, Paul and Ren, Dacheng (2020) Sensing the unreachable: challenges and opportunities in biofilm detection. Current Opinion in Biotechnology, 64, 79-84. (doi:10.1016/j.copbio.2019.10.009).

Record type: Article

Abstract

Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corrosion, to drug resistant infections. Besides the challenges in control, biofilms are also difficult to detect due to the lack of biofilm-specific biomarkers and methods for non-destructive imaging. In this article, we present a concise review of recent advancements in this field, with a focus on medical device-associated infections. We also discuss the technologies that have potential for non-destructive detection of bacterial biofilms.

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Current Opinion Review _Revision - Accepted Manuscript
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Accepted/In Press date: 30 October 2019
e-pub ahead of print date: 22 November 2019
Published date: August 2020
Additional Information: Funding Information: The authors thank the U.S. National Science Foundation for an ERC planning grant ( 1936926 ), which facilitates discussions of future research on microbial control and partially led to this review article. PS is funded by the NIH R01GM124436. DR's current research on catheters is supported by NIH 1R21AI142424-01. Publisher Copyright: © 2019 Elsevier Ltd

Identifiers

Local EPrints ID: 435623
URI: http://eprints.soton.ac.uk/id/eprint/435623
ISSN: 0958-1669
PURE UUID: e2d5ca7d-d4a2-4d10-9ddc-7459cd7a23ce
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

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Date deposited: 14 Nov 2019 17:30
Last modified: 02 Aug 2022 04:01

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Contributors

Author: Yikang Xu
Author: Yousr Dhaouadi
Author: Paul Stoodley ORCID iD
Author: Dacheng Ren

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