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Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries

Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries
Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries
Anti-Retroviral Therapy (ART) is the recommended first line therapy for patients with HIV. Since 2004, Chinese government has provided free Chinese herbal medicine (CHM) for Chinese HIV/AIDS patients. Data of living patients with HIV from the NFTCMP database and Center for Disease Control (CDC) database during 2003-2016 in Guangxi province was obtained and compared. Patients were divided into 3 groups according to their recorded treatment regimens. A total of 2954 patients with their treatment recorded in the two databases were included for analysis, their median age was 46 years (IQR = 36-59), and 64.63% were male. CHM regimens users had baseline CD4 cell counts (380.11±240.59 cell/μL), approximately 100 cell/μL significantly higher than patients receiving CHM combined with ART regimens or only ART regimens. There was no significant difference in mortality among groups. All three regimens improved patients’ CD4 cell counts. Compared to the sharp improvement in ART group during the first 6 months, CD4 cell counts of patients in CHM group and CHM combined with ART group showed a smooth and steady rise. CD4 counts of the combined group remained much lower than ART group in the first 3 years, but overtook ART group in the fourth year.
2045-2322
Sun, Jin
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Jiang, Feng
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Wen, Bin
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Liu, Zhen-Wei
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Han, Mei
94e2baee-f8b0-4bd9-9e5b-83d33f464683
Robinson, Nicola
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Mcgrath, Nuala
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Fei, Yu-Tong
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Zhang, Ying
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Li, Jing
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Li, Wen-Juan
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Deng, Xin
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Liu, Jian Ping
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Sun, Jin
06da3d5f-93d0-4768-8e6b-4523fb48aa52
Jiang, Feng
795b8362-23d4-4e71-980f-e925c772f14f
Wen, Bin
128f5ec5-e1a5-43a4-8958-98be61456915
Liu, Zhen-Wei
559822a3-1c7d-4989-bb38-cd6f912ea998
Han, Mei
94e2baee-f8b0-4bd9-9e5b-83d33f464683
Robinson, Nicola
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Mcgrath, Nuala
b75c0232-24ec-443f-93a9-69e9e12dc961
Fei, Yu-Tong
4aed6774-69e6-423c-80a4-e49e9ee65f40
Zhang, Ying
a1a5b530-992a-41b3-94d8-043590122036
Li, Jing
fafa4088-5b81-4c81-9228-ae4da619d9ff
Li, Wen-Juan
c6a345bf-df1b-4464-a041-28fe3f9b1a5e
Deng, Xin
bd22df1a-a4a4-4438-b3f4-3381b3901b3b
Liu, Jian Ping
4c1de9c3-e9c2-4d4e-a0a4-dad123a39c76

Sun, Jin, Jiang, Feng, Wen, Bin, Liu, Zhen-Wei, Han, Mei, Robinson, Nicola, Mcgrath, Nuala, Fei, Yu-Tong, Zhang, Ying, Li, Jing, Li, Wen-Juan, Deng, Xin and Liu, Jian Ping (2019) Chinese herbal medicine for patients living with HIV in Guangxi province, China: an analysis of two registries. Scientific Reports, 9, [17444]. (doi:10.1038/s41598-019-53725-x).

Record type: Article

Abstract

Anti-Retroviral Therapy (ART) is the recommended first line therapy for patients with HIV. Since 2004, Chinese government has provided free Chinese herbal medicine (CHM) for Chinese HIV/AIDS patients. Data of living patients with HIV from the NFTCMP database and Center for Disease Control (CDC) database during 2003-2016 in Guangxi province was obtained and compared. Patients were divided into 3 groups according to their recorded treatment regimens. A total of 2954 patients with their treatment recorded in the two databases were included for analysis, their median age was 46 years (IQR = 36-59), and 64.63% were male. CHM regimens users had baseline CD4 cell counts (380.11±240.59 cell/μL), approximately 100 cell/μL significantly higher than patients receiving CHM combined with ART regimens or only ART regimens. There was no significant difference in mortality among groups. All three regimens improved patients’ CD4 cell counts. Compared to the sharp improvement in ART group during the first 6 months, CD4 cell counts of patients in CHM group and CHM combined with ART group showed a smooth and steady rise. CD4 counts of the combined group remained much lower than ART group in the first 3 years, but overtook ART group in the fourth year.

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Chinese herbal medicine for patients living with HIV in Guangxi province China_ an analysis of two registries_resubmitted_version_Nov2019 - Accepted Manuscript
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More information

Submitted date: 31 October 2019
Accepted/In Press date: 31 October 2019
e-pub ahead of print date: 25 November 2019
Published date: November 2019

Identifiers

Local EPrints ID: 436028
URI: http://eprints.soton.ac.uk/id/eprint/436028
ISSN: 2045-2322
PURE UUID: 2a1f9923-4816-42f1-894c-b5c60fd18ae4
ORCID for Nuala Mcgrath: ORCID iD orcid.org/0000-0002-1039-0159

Catalogue record

Date deposited: 26 Nov 2019 17:30
Last modified: 09 Jan 2022 03:43

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Contributors

Author: Jin Sun
Author: Feng Jiang
Author: Bin Wen
Author: Zhen-Wei Liu
Author: Mei Han
Author: Nicola Robinson
Author: Nuala Mcgrath ORCID iD
Author: Yu-Tong Fei
Author: Ying Zhang
Author: Jing Li
Author: Wen-Juan Li
Author: Xin Deng
Author: Jian Ping Liu

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