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Intergenerational effect of early life growth on offspring height: evidence from the Hertfordshire Cohort Study

Intergenerational effect of early life growth on offspring height: evidence from the Hertfordshire Cohort Study
Intergenerational effect of early life growth on offspring height: evidence from the Hertfordshire Cohort Study
Background: previous intergenerational (parent to child) and transgenerational (grandparent to grandchild) studies have shown there is a link between parental and offspring birthweight.

Objectives: the aim was to explore the association between the early life weight gain of an individual and the adult height of their children and grandchildren.

Methods: study participants across three generations of the Hertfordshire Cohort Study (HCS) were included in this study. Health visitors recorded the birthweight (kg) and weight at 1 year (kg) of the original (F0 generation) HCS participants when they were born in Hertfordshire between 1931 and 1939. A conditional infant weight gain score for F0 participants was calculated using birthweight and weight at 1 year, and self-reported height (cm) of their children (F1 generation) and their grandchildren (F2 generation) was obtained from postal questionnaires. Due to lack of clustering within family lines, linear regression analysis was used to compare intergenerational relationships.

Results: data were available from 139 F0, 148 F1, and 198 F2 participants. A positive association was found between parent birthweight (F0) and offspring adult height; on average, a 1 kg increase in F0 birthweight was associated with a 2.04 cm increase in F1 adult height (beta 2.04, 95% confidence interval (CI) -0.03, 4.10). A positive association was found between F0 conditional weight gain during the first year of life and offspring (beta 1.53, 95% CI 0.45, 2.62) and grandchild height (beta 1.06, 95% CI 0.03, 2.10). Positive associations were also found between F0 weight at 1 year and offspring (beta 1.83, 95% CI 0.79, 2.87) and grandchild height (beta 0.91, 95% CI -0.10, 1.91).

Conclusion: this study demonstrates an association between grandparental weight gain in early life and the heights of their children and grandchildren. The results of these analyses highlight the importance of early life weight gain on the adult stature of subsequent offspring.
family health, intergenerational health, population health, social determinants of health
0269-5022
29-35
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Carter, Sarah
a5111bba-b67c-47ec-b74a-b0bcef477fe6
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Syddall, Holly Emma
a0181a93-8fc3-4998-a996-7963f0128328
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Carter, Sarah
a5111bba-b67c-47ec-b74a-b0bcef477fe6
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Syddall, Holly Emma
a0181a93-8fc3-4998-a996-7963f0128328
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1

Parsons, Camille, Carter, Sarah, Ward, Kathryn, Syddall, Holly Emma, Clynes, Michael, Cooper, Cyrus and Dennison, Elaine (2020) Intergenerational effect of early life growth on offspring height: evidence from the Hertfordshire Cohort Study. Paediatric and Perinatal Epidemiology, 34 (1), 29-35. (doi:10.1111/ppe.12620).

Record type: Article

Abstract

Background: previous intergenerational (parent to child) and transgenerational (grandparent to grandchild) studies have shown there is a link between parental and offspring birthweight.

Objectives: the aim was to explore the association between the early life weight gain of an individual and the adult height of their children and grandchildren.

Methods: study participants across three generations of the Hertfordshire Cohort Study (HCS) were included in this study. Health visitors recorded the birthweight (kg) and weight at 1 year (kg) of the original (F0 generation) HCS participants when they were born in Hertfordshire between 1931 and 1939. A conditional infant weight gain score for F0 participants was calculated using birthweight and weight at 1 year, and self-reported height (cm) of their children (F1 generation) and their grandchildren (F2 generation) was obtained from postal questionnaires. Due to lack of clustering within family lines, linear regression analysis was used to compare intergenerational relationships.

Results: data were available from 139 F0, 148 F1, and 198 F2 participants. A positive association was found between parent birthweight (F0) and offspring adult height; on average, a 1 kg increase in F0 birthweight was associated with a 2.04 cm increase in F1 adult height (beta 2.04, 95% confidence interval (CI) -0.03, 4.10). A positive association was found between F0 conditional weight gain during the first year of life and offspring (beta 1.53, 95% CI 0.45, 2.62) and grandchild height (beta 1.06, 95% CI 0.03, 2.10). Positive associations were also found between F0 weight at 1 year and offspring (beta 1.83, 95% CI 0.79, 2.87) and grandchild height (beta 0.91, 95% CI -0.10, 1.91).

Conclusion: this study demonstrates an association between grandparental weight gain in early life and the heights of their children and grandchildren. The results of these analyses highlight the importance of early life weight gain on the adult stature of subsequent offspring.

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130120 Intergenerational_effect_of_early_life_growth_manuscript for PURE - Accepted Manuscript
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Accepted/In Press date: 15 October 2019
e-pub ahead of print date: 20 January 2020
Published date: January 2020
Keywords: family health, intergenerational health, population health, social determinants of health

Identifiers

Local EPrints ID: 437164
URI: http://eprints.soton.ac.uk/id/eprint/437164
ISSN: 0269-5022
PURE UUID: 85eff5af-70bc-415c-b76d-dc1f9e9ce75f
ORCID for Kathryn Ward: ORCID iD orcid.org/0000-0001-7034-6750
ORCID for Holly Emma Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for Michael Clynes: ORCID iD orcid.org/0000-0001-7597-7658
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961

Catalogue record

Date deposited: 20 Jan 2020 17:32
Last modified: 26 Nov 2021 06:14

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Contributors

Author: Camille Parsons
Author: Sarah Carter
Author: Kathryn Ward ORCID iD
Author: Michael Clynes ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Elaine Dennison ORCID iD

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