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Clinical research tools in pediatric oncology:: challenges and opportunities

Clinical research tools in pediatric oncology:: challenges and opportunities
Clinical research tools in pediatric oncology:: challenges and opportunities
Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct and that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.
AYA oncology, CTCAE, Childhood cancer, Quality assurance, Quality of life, RECIST
0167-7659
149-160
de Rojas, Teresa
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Neven, Anouk
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Towbin, Alexander J.
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Carceller, Fernando
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Bautista, Francisco
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Riedl, David
dd01d4ed-3140-4f77-9923-883a04a4c136
Sodergren, Samantha
d66fc3fa-2c98-403d-8ae5-410ef95de46e
Darlington, Anne-Sophie
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Fernandez-Teijeiro, Ana
ae0b5c7b-b2a0-4105-810b-e68d69f69977
Moreno, Lucas
25f0eebb-928a-4d37-b4ff-6e65aab0ab0e
de Rojas, Teresa
799aa1fb-52f8-4ecf-973a-632cfce7ad2f
Neven, Anouk
92a2968e-e211-46a9-86a9-6a60d5e6f706
Towbin, Alexander J.
4555295c-e83f-4322-b858-880e02b4d507
Carceller, Fernando
77fc8439-8b41-4aca-b573-84e097d5e8da
Bautista, Francisco
25005ad2-818a-4cb5-975b-bd6fde9abf36
Riedl, David
dd01d4ed-3140-4f77-9923-883a04a4c136
Sodergren, Samantha
d66fc3fa-2c98-403d-8ae5-410ef95de46e
Darlington, Anne-Sophie
472fcfc9-160b-4344-8113-8dd8760ff962
Fernandez-Teijeiro, Ana
ae0b5c7b-b2a0-4105-810b-e68d69f69977
Moreno, Lucas
25f0eebb-928a-4d37-b4ff-6e65aab0ab0e

de Rojas, Teresa, Neven, Anouk, Towbin, Alexander J., Carceller, Fernando, Bautista, Francisco, Riedl, David, Sodergren, Samantha, Darlington, Anne-Sophie, Fernandez-Teijeiro, Ana and Moreno, Lucas (2020) Clinical research tools in pediatric oncology:: challenges and opportunities. Cancer and Metastasis Reviews, 39 (1), 149-160. (doi:10.1007/s10555-020-09856-z).

Record type: Article

Abstract

Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct and that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.

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Clinical research tools in pediatric oncology challenges and opportunities - Accepted Manuscript
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Accepted/In Press date: 26 December 2019
e-pub ahead of print date: 15 January 2020
Keywords: AYA oncology, CTCAE, Childhood cancer, Quality assurance, Quality of life, RECIST

Identifiers

Local EPrints ID: 437285
URI: http://eprints.soton.ac.uk/id/eprint/437285
ISSN: 0167-7659
PURE UUID: b7a61550-030e-4431-a699-d2d073d7b477
ORCID for Samantha Sodergren: ORCID iD orcid.org/0000-0001-8755-146X

Catalogue record

Date deposited: 23 Jan 2020 17:34
Last modified: 26 Nov 2021 05:55

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Contributors

Author: Teresa de Rojas
Author: Anouk Neven
Author: Alexander J. Towbin
Author: Fernando Carceller
Author: Francisco Bautista
Author: David Riedl
Author: Ana Fernandez-Teijeiro
Author: Lucas Moreno

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