Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model
Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model
Summary: Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective: This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.
Epidemiology, FRAX, Fracture probability, Hip fracture
1-8
Zakroyeva, Alla
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Lesnyak, O.
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Cazac, Victor
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Groppa, Lillian
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Russu, Eugen
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Chrislari, Lia
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Rotaru, Larisa
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Johansson, Helena
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Harvey, Nicholas
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McCloskey, Eugene
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Lorentzon, M.
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Kanis, John A.
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1 December 2020
Zakroyeva, Alla
cd5a3017-965e-4182-89bd-2ff944350a3e
Lesnyak, O.
79b8479e-2590-4bc1-8fbe-1f5941edc13e
Cazac, Victor
fd78c9b4-54de-47a6-84df-a0948dcad57b
Groppa, Lillian
5b7387e3-9f4e-4f2d-8c77-aba2d7576b19
Russu, Eugen
6d1a4edc-2aca-4775-b70f-41e035e1f42b
Chrislari, Lia
6d58ad16-9912-4ac7-a661-45ae92b44db4
Rotaru, Larisa
b1d24de8-9b95-4de3-897c-a2612b95d9bf
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Lorentzon, M.
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Kanis, John A.
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Zakroyeva, Alla, Lesnyak, O., Cazac, Victor, Groppa, Lillian, Russu, Eugen, Chrislari, Lia, Rotaru, Larisa, Johansson, Helena, Harvey, Nicholas, McCloskey, Eugene, Lorentzon, M. and Kanis, John A.
(2020)
Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model.
Archives of Osteoporosis, 15 (1), , [13].
(doi:10.1007/s11657-019-0669-z).
Abstract
Summary: Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective: This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.
Text
MOLDOVA OSIN revision
- Accepted Manuscript
More information
Accepted/In Press date: 4 November 2019
e-pub ahead of print date: 28 January 2020
Published date: 1 December 2020
Additional Information:
Funding Information:
The authors would like to thank the administration of Orhei and Anenii Noi county hospitals for their support.
Publisher Copyright:
© 2020, The Author(s).
Keywords:
Epidemiology, FRAX, Fracture probability, Hip fracture
Identifiers
Local EPrints ID: 437611
URI: http://eprints.soton.ac.uk/id/eprint/437611
ISSN: 1862-3522
PURE UUID: 49b4665c-f5a2-434c-bd67-7e1e2ebc6232
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Date deposited: 06 Feb 2020 17:32
Last modified: 17 Mar 2024 02:58
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Contributors
Author:
Alla Zakroyeva
Author:
O. Lesnyak
Author:
Victor Cazac
Author:
Lillian Groppa
Author:
Eugen Russu
Author:
Lia Chrislari
Author:
Larisa Rotaru
Author:
Helena Johansson
Author:
Eugene McCloskey
Author:
M. Lorentzon
Author:
John A. Kanis
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